Call your doctor immediately if you experience warning signs such as chest pain, shortness of breath, or fainting while taking amantadine.Share a history of seizures with your physician. All rights reserved. Amantadine is an antiviral medication used to prevent or treat certain influenza infections; it is also given as an adjunct for the treatment of Parkinson's disease. If chewed and swallowed, may result in a lower peak concentration and bioavailability.Irritant; Note: chewed, crushed, or sucked tablets may cause oropharyngeal ulceration.Note: crushing the 23 mg tablet may significantly increase the rate of absorption; the 5 mg and 10 mg tablets are not affectedSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose.Slow-release; Note: chewed, cut, or crushed tablets may cause oropharyngeal irritationMucous membrane irritation; Note: drug may cause fetal abnormalities; women who are, or may become, pregnant, should not handle capsules; all women should use caution in handling capsules, especially leaking capsulesSublingual form (g); Note: chewing or swallowing may result in lower bioavailability.Note: chewed, crushed, or sucked tablets may cause oropharyngeal irritationAntineoplastic; Note: crushed or broken tablets should not be handledNote: chewing or swallowing may result in lower peak concentrations and bioavailabilitySlow-release; Note: may expose to potentially fatal overdoseNote: tablets should be dispersed completely in waterNote: although not in the package insert, the drug has a coating that is intended to release the drug over approximately 3 hoursNote: capsules may be opened and the contents mixed with food/drinkSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose.Slow-release (a) (Note: may add contents of capsule to chilled, not warm, applesauce and consume immediately)Slow-release; oral disintegrating tablet designed to disintegrate on the tongue.Taste; Note: capsule may be opened and mixed with fruit puree (e.g., banana)Note: drug may be crushed but company recommends using injectionNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerSlow-release (a); Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: package insert indicates potential teratogenic effects; material safety data sheet warns against skin contact; health care workers should take appropriate precautionsSlow-release (Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal dose)Note: do not give as whole tablet, tablets are meant to be given as oral suspension; see company insertMucous membrane irritant; Note: may be dissolved in water or apple juiceNote: not scored; no studies available from companyNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseAntineoplastic; Note: not scored; no studies available from companySlow-release (h); Note: 30mg tablet may not be splitNote: not scored; no studies available from companyNote: tablet should be swallowed whole and not crushed; tablet may be dispersed in waterNote: tablet may be dissolved in 4-8 ounces of waterNote: see prescribing information for making a suspensionMucous membrane irritant; Note: women who are, or may become, pregnant, should not handle crushed or broken tablets (l)Slow-release (a) (Note: do not give via NG tubes; crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal dose)Note: not scored; no studies available from companyTaste (b) (Note: some extemporaneous formulas are pharmacy prepared)Slow-release (Note: tablet matrix may remain in stool)Slow-release (b); Note: crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal doseSlow-release (b); Note: crushing, chewing or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: crushing tablets has resulted in decreased bioavailability of drug (b)Slow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseSlow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: not amenable to crushing; may obstruct feeding tubes (b)Slow-release; Note: crushing, chewing, or dissolving tablets can cause rapid release and absorption of a potentially fatal doseNote: breaking, chewing, or emptying contents of the capsule can result in increased exposureNote: see package insert for administration instructions via an oral syringe of NG tubeNote: pharmacokinetics may be altered if not taken wholeNote: women who are, or may become, pregnant, should not handle crushed or broken tabletsNote: women who are, or may become, pregnant, should not handle crushed or broken tabletsNote: pharmacokinetic parameters may be affected (b)Slow-release; Note: delayed release is dependent on an intact coating (b)Note: Teratogenic potential; health care workers should avoid contact with capsule contents/body fluidsNote: an oral powder is available, see prescribing information for administration instructionsNote: tablets are not scored and cutting may cause variable dosage accuracyNote: exposure to the powder may cause serious skin toxicities; health care workers should wear gloves to administerFilm-coated (Note: active ingredients are surrounded by wax matrix to prevent healthcare exposure; women who are, or may become, pregnant should not handle crushed or broken tablet)Note: combining multiple tablets or portions of tablets may lead to an overdose of entacaponeNote: disruption of capsule may yield high blood levels causing enhanced toxicity (a)Empty contents into a spoon for administration.