5-7 mg/kg/day PO divided q6hr for 7 days; UTI prophylaxis: 1-2 mg/kg PO qHS or 2 divided doses >12 years. * Approximation only. Dose Adjustments-Elderly patients: A lower loading dose and/or infusion rate, and lower or less frequent maintenance dosing may be required. Table 1: Intravenous phenytoin loading dose. 45 to 54. All rights reserved. 1450. Table 1 - IV phenytoin loading dose. Then normal maintenance dosage started 24 hours after loading dose. It is recommended that patients use the information presented as a part of a broader decision-making process.If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.© 2020 eHealthMe.com. Drug interactions are reported among people who take Phenytoin sodium and Macrobid together. It can also be used to control or prevent seizures during or after brain surgery and/or severe head injury. Guideline for Phenytoin Dose Calculations 1. Phenytoin: Monitor serum phenytoin levels: Sulfamethoxazole and Trimethoprim Injection may inhibit the hepatic metabolism of phenytoin (a CYP2C9 substrate). Direct IV injection presents well‐recognised side effects which can be minimised by giving phenytoin as an infusion. If the patient has not already received phenytoin then give: Phenytoin sodium IV 18mg/kg (see Table 1 below). and you may need to create a new Wiley Online Library account.Enter your email address below and we will send you your usernameIf the address matches an existing account you will receive an email with instructions to retrieve your username Continuously monitor electrocardiogram (ECG), blood pressure, and respiratory status during and until 1 hour after the infusion. Macrocrystals (Macrodantin, Furadantin, and equivalents): 50-100 mg PO q6hr for 7 days or for 3 days after obtaining sterile urine I guess while we’ve wandered into adverse effects, we might as well do it right. 65 to 74. Drug interactions are reported among people who take Phenytoin and Macrobid together. 1250. Unbound phenytoin concentrations may be more useful. Administration of phenytoin via enteral feeding tubes is not recommended due to variable absorption of phenytoin. Drug interactions are reported among people who take Phenytoin sodium and Macrobid together. * Approximation only. 14. Because of this the FDA has added a warning to the prescribing information for phenytoin that suggests cardiac monitoring occur during and after IV phenytoin administration. generic drugs) are not considered. Free E-newsletter Subscribe to Housecall. Ensure ECG, blood pressure and respiratory function are monitored throughout the duration of the infusion. The study is created by eHealthMe based on reports of 7 people who take Phenytoin sodium and Macrobid from the FDA, and is updated regularly. Drug information provided by: IBM Micromedex. 700. Side Effects. Regardless of whether you use phenytoin or fosphenytoin, we need to monitor for adverse effects, including cardiac toxicities like hypotension and arrhythmias. Phenytoin (Injection Route) Print. Use IV phenytoin only when oral administration is not possible, due to potential cardiovascular and local toxicity. Sections. Cardiac toxicity may occur with phenytoin administration, even at normal infusion rates. All rights reserved. generic drugs) are not considered. Phenytoin Accord can be used to treat severe epileptic seizures or fits (status epilepticus). Actual body weight (kg) Intravenous loading dose (mg) Volume of intravenous phenytoin (mL) (vial = 250mg/5mL) 35 to 44. Urinary Tract Infection >1 month. Description and Brand Names; Before Using; Proper Use; Precautions; Side Effects; Products and services. 32 >94. The study is created by eHealthMe based on reports of 7 people who take Phenytoin sodium and Macrobid from the FDA, and is updated regularly. 25. The study is based on nitrofurantoin, macrocrystalline and phenytoin (the active ingredients of Nitrofurantoin and Phenytoin, respectively), and Nitrofurantoin and Phenytoin (the brand names). Ensure ECG, blood pressure and respiratory function are monitored throughout the duration of the infusion.