Allopurinol is in a class of medications called xanthine oxidase inhibitors. To reduce the possibility of flare-up of acute gouty attacks, it is recommended that the patient start with a low dose of Allopurinol tablets (100 mg daily) and increase at weekly intervals by 100 mg until a serum uric acid level of 6 mg/dL or less is attained but without exceeding the maximal recommended dosage.100-mg (white to off white) scored, flat cylindrical tablets with "I" and "135" on either side of the break line on one side and plain on other side, bottles of 100 (NDC 69967-008-01), 500 (NDC 69967-008-02) and 1000 (NDC 69967-008-03).300-mg (peach) scored, flat, cylindrical tablet with "I" and "136" on either side of the break line on one side and plain on other side, bottles of 100 (NDC 69967-009-01), 500 (NDC 69967-009-02)and 1000 (NDC 69967-009-03) .The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The average is 200 to 300 mg/day for patients with mild gout and 400 to 600 mg/day for those with moderately severe tophaceous gout. If you are receiving care at another medical facility, Mayo Clinic recommends you share this information with your other health care providers.Allopurinol is also used to prevent or treat high uric acid levels that may be caused by cancer medicines or for patients with kidney stones that contain calcium.Variants in a gene called HLA-B can affect how you respond to allopurinol. The appropriate dosage may be administered in divided doses or as a single equivalent dose with the 300-mg tablet. Keep taking this medicine (allopurinol tablets) as you have been told by your doctor or other health care provider, even if you feel well. laboratory. vides data about laboratory monitoring of allopurinol and. You may also report side effects at https://www.fda.gov/medwatch. taken, how much, and when it happened. Your doctor may prescribe another medication such as colchicine to prevent gout attacks for the first few months you take allopurinol. ZYLOPRIM (allopurinol) is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one.It is a xanthine oxidase inhibitor which is administered orally. It reduces the production of uric acid by inhibiting the biochemical reactions immediately preceding its formation.It has been shown that reutilization of both hypoxanthine and xanthine for nucleotide and nucleic acid synthesis is markedly enhanced when their oxidations are inhibited by Allopurinol and oxipurinol. Use this medicine (allopurinol tablets) as ordered by your doctor. For NSAIDs, colchicine, and allopurinol, full blood count, renal function tests, and liver function tests should be obtained every 3 to 6 months. monitor as recommended. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. Call your doctor for medical Read all information given to you. Ask your pharmacist any questions you have about refilling your prescription.It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Your doctor may prescribe another medication such as colchicine to prevent gout attacks for the first few months you take allopurinol. Emphasis is on routine monitoring, as opposed to symptom-triggered monitoring (e.g., checking amylase in event of pancreatitis symptoms). The minimal effective dosage is 100 to 200 mg daily and the maximal recommended dosage is 800 mg daily. Information provided applies to adults. In some situations, signs or symptoms may be People with a certain variant in this gene called Toxic epidermal necrolysis is a more serious form of Stevens-Johnson syndrome in which a larger area of the skin or mucous membranes is affected.Most patients treated with allopurinol who develop toxic epidermal necrolysis or These resources may help you understand more about individualized medicine, genomics and drug-gene testing (pharmacogenomics):If you have questions about your test results, ask to speak with your health care provider at your Mayo Clinic care location:Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. To help you remember to take allopurinol, take it around the same time every day. provides the impetus to assess implications of failure to. When initiating allopurinol, patients should be closely monitored for hypersensitivity syndrome (eosinophilia, dermatitis, and … Tell your Talk to your doctor about the possible risks of using this medication for your condition.This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.Drink at least eight glasses of water or other fluids each day while taking allopurinol unless directed to do otherwise by your doctor.Take the missed dose as soon as you remember it. Dosage requirements in excess of 300 mg should be administered in divided doses. advice about side effects.