Discover Your Allergy Triggers There is no interaction between them. Sudafed is still Sudafed. eHealthMe has been monitoring drugs since 2008. Claritin-D is a combination product. Benadryl is also an antihistamine used to treat other Sudafed is also used to relieve nasal congestion due to the Benadryl and Sudafed belong to different drug classes. You should not take 4 Benadryl either. If you do not have a dose-measuring device, ask your pharmacist for one.Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash.If you need surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.This medication can cause unusual results with allergy skin tests. Select one or more newsletters to continue. Since it contains pseudoephedrine, a regulated OTC product, you may need to purchase it ‘behind the counter’ of the pharmacy. For Nasal Congestion: Currently taking pseudoephedrine for chronic sinus migraines and ear congestion whilst waiting for a specialist appointment. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.Ask a doctor or pharmacist if it is safe for you to take diphenhydramine and pseudoephedrine if you have:It is not known whether diphenhydramine and pseudoephedrine will harm an unborn baby. Cold medicine is usually taken only for a short time until your symptoms clear up.Do not give this medication to a child younger than 4 years old. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, Skip the missed dose if it is almost time for your next scheduled dose. Drug interactions are reported among people who take Sudafed and Benadryl together. You may also report side effects at https://www.fda.gov/medwatch. Follow all instructions closely. No, do not take 8 Benadryl at a time to help you sleep. * Approximation only. Read all information given to you. Benadryl is an antihistamine and Sudafed is a Sudafed (pseudoephedrine HCI) is a decongestant prescribed for the temporary relief of nasal congestion due to the common cold, Benadryl may interact with other medicines that make you sleepy (such as cold or allergy medicine, sedatives, Benadryl may also interact with monoamine oxidase inhibitors (MAOIs).Sudafed may interact with monoamine oxidase inhibitors (MAOIs) and Copyright © 2020 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. A dangerous drug interaction could occur. Do not take 2 doses at the same time or extra doses. All rights reserved. Version: 7.01. These are not all of the side effects that may occur. Many combination medicines contain diphenhydramine or pseudoephedrine. However, many people have no side effects or only have minor side effects. advice about side effects. Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Be careful if you drive or do anything that requires you to be alert and able to see clearly.Drinking alcohol with this medicine can cause side effects.Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Do not take extra medicine to make up the missed dose.Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.This medication may cause blurred vision and may impair your thinking or reactions. Use Benadryl Allergy/Cold (acetaminophen, diphenhydramine, and pseudoephedrine tablets) as ordered by your doctor. You may report side effects to FDA at 1-800-FDA-1088.2 tablets (25 mg-30 mg) or 2 disintegrating tablet (12.5 mg-30 mg) or 10 mL liquid (12.5 mg-30 mg/5 mL) every 4 to 6 hours as needed.