It remains unclear whether steroid could benefit other subsets of ARDS patients (e.g. The results of the other four arms of the RECOVERY trial are eagerly awaited. Dexamethasone is a steroid that can be … I wouldn’t normally start oxygen until the room air saturation fell below 90%, and I go even lower in patients with chronic lung disease. Mix. Will a lower dose of dexamethasone for a longer duration (10 days vs three-five days) make a difference? Assessment of Proteasome Inhibition for Extending Remissions (APEX) was a Phase 3 clinical trial conducted in 2002-2003 to ascertain the efficacy of Bortezomib, a proteasome inhibitor, against relapsed multiple myeloma in comparison to that of high dose dexamethasone, the accepted treatment of the disease at the time. Share on Reddit; In March 2020, the RECOVERY (Randomised Evaluation of COVid-19 thERapY) trial was established as a randomised clinical trial to test a range of potential treatments for COVID-19, including low-dose dexamethasone (a steroid treatment). The analysis – which pooled data from separate trials of low dose hydrocortisone, dexamethasone and methylprednisolone – found that steroids improve survival rates of COVID-19 patients sick enough to be in intensive care in hospital.“This is equivalent to around 68 per cent of (the sickest COVID-19) patients surviving after treatment with corticosteroids, compared to around 60% surviving in the absence of corticosteroids,” the researchers said in a statement.“Steroids are a cheap and readily available medication, and our analysis has confirmed that they are effective in reducing deaths amongst the people most severely affected by COVID-19,” Jonathan Sterne, a professor of medical statistics and epidemiology at Britain’s Bristol University who worked on the analysis, told the briefing.He said the trials – conducted by researchers in Britain, Brazil, Canada, China, France, Spain, and the United States – gave a consistent message throughout, showing the drugs were beneficial in the sickest patients regardless of age or sex or how long patients had been ill.The findings, published in the Journal of the American Medical Association, reinforce results that were hailed as a major breakthrough and announced in June, when dexamethasone became the first drug shown to be able to reduce death rates among severely sick COVID-19 patients.Dexamethasone has been in widespread use in intensive care wards treating COVID-19 patients in some countries since then.Martin Landray, a professor of medicine and epidemiology at the University of Oxford who worked on the dexamethasone trial that was a key part of the pooled analysis published on Wednesday, said the results mean doctors in hospitals across the world can safely switch to using the drugs to save lives.“These results are clear, and instantly usable in clinical practice,” he told reporters. It has six arms, testing six different treatments in patients. We have enabled email notifications—you will now receive an email if you receive a reply to your comment, there is an update to a comment thread you follow or if a user you follow comments. They are required for sustaining many vital functions of the body. A drug known for decades is being hailed as a wonder cure for Covid-19 after the study group conducting a clinical trial in United Kingdom said Dexamethasone The hype around Dexamethasone reminds us of the time when Hydroxychloroquine was announced as a “cure” for Covid-19. It is a complication of many illnesses like toxins, drowning, bacterial and viral pneumonias (including Covid-19). We ask you to keep your comments relevant and respectful. The study divides 669 patients with relapsed … Packages of Dexamethasone are displayed in a pharmacy, Tuesday, June 16, 2020, in Omaha, Neb. 1. The results are still awaited on its utility as a pre-exposure drug and for mild illness. LINE. If you have high blood sugar (diabetes), you will need to watch your blood sugar closely. One death would be prevented by treating around eight patients on ventilator, while among patients on oxygen support, one death would be prevented by treating 25 patients.There was no benefit among those patients who did not require respiratory support.