Management of extravasation should be conducted at the discretion of the clinician in collaboration with all members of the health care team. Histologic examination of his patient showed no evidence of dermal or epidermal damage.Even when sclerotherapy is performed with expert technique, using the safest sclerosing solutions and concentrations, cutaneous ulceration may occur. A list of the kit’s contents should be placed within the kit and regular verification of the drug contents with updated expiration dates should be maintained regularly by a pharmacist.Once vesicant extravasation occurs, the clinician should immediately stop the infusion; however, the cannula or noncoring port needle should be kept in place and an attempt to aspirate the vesicant with a 10-mL syringe should be made. One patient complained of mildly painful induration 3 months after the extravasation of vincristine.Dexrazoxane efficacy was demonstrated in two clinical trials conducted in Europe.Patients were assessed for efficacy and safety at days 7, 14, 21, and 28, and for efficacy at day 90.The most common adverse effects included a decreased white blood cell count (72.5%), decreased hemoglobin (42.5%), decreased platelet count (26%), increased aspartate aminotransferase (36.8%), increased alanine aminotransferase (23.9%), injection site reaction (27.5%), and nausea (18.8%).A summary of these treatment recommendations, including the EONS 2007 guidelines, is provided in Pharmacists should be closely involved in the assessment and management of all chemotherapy-induced extravasations. Common Questions and Answers about Acyclovir extravasation. Symptoms of Extravasation The early symptoms of extravasation include the following: Swelling, pain, erythema, and blistering. In addition, the patient and his relatives are instructed and are called in for regular controls. Some examples of irritants commonly given in the treatment of Karen Raymaakers RN, CON(C) is a certified oncology nurse that has worked with leukemia and lymphoma patients for over a decade. According to the Infusion Nurses Society and the Oncology Nursing Society, both complications involve the inadvertent leakage of an IV solution into surrounding tissue; however, the type of solution differs. IV device factors that affect extravasation risk include needle material (i.e., metal), cannula size (large plastic vs. small plastic), and catheter type (i.e., central venous catheter [CVC]). 1. A gradual increase in pressure may indicate extravasation / thrombus formation. Increased resistance when administering medications intravenously. These signs may be absent initially if the drug leaks into the tissue slowly after completion of the drug administration. During vesicant administration, the site should be monitored for swelling, redness, and pain. Signs and symptoms of extravasation: 1.2.1. Title: Microsoft Word - Extravasation Treatment Table Non-Chemo June 2016.docx Author: fostersj Created Date: 8/12/2016 1:10:46 PM This approach is not recommended generally, but it can be useful in special cases, such as with extravasation of a highly vesicant compound at the dorsum of the hand or from a central venous device.The type of reaction is based on the agent's potential for local toxicity. Documentation serves several purposes, including providing an accurate account of what happened, protecting the health care professionals involved, gathering information on extravasations, and highlighting deficits in practice.Signs and symptoms of vesicant extravasation include swelling, redness, and/or discomfort that are often described as burning or stinging. However, when vesicant medications leak out of the vein and make contact with the tissue, the damage begins. No steroids or cold packs were applied. Acyclovir Injection is a sterile solution containing acyclovir 25 mg/mL. Read our Rarely the injection of a strong sclerosing solution into a fragile vessel may lead to endothelial necrosis and rupture, producing a “blow-out” of the vessel and perivascular extravasation of sclerosing solution. This regimen provided pain relief and ulcer prevention.Olver and Schwarz reported three cases of extravasation resolution with DMSO use.Berghammer et al also reported a case of docetaxel extravasation.Ludwig et al reported that the use of a DMSO 90% and alpha-tocopherol 10% mixture within 48 hours after extravasations of anthracyclines or mitomycin C in 8 patients resulted in no skin ulceration or functional or neurovascular impairment.In a prospective study of 20 patients with anthracycline extravasations, DMSO 99% was administered twice, 6 times daily for 2 weeks.In these case reports and small studies, extravasations were diagnosed clinically and not by biopsy.