(See Fluconazole increases the AUC of saquinavir by approximately 50%, CFollowing oral administration of midazolam, fluconazole resulted in substantial increases in midazolam concentrations and psychomotor effects. In normal volunteers, saliva concentrations of fluconazole were equal to or slightly greater than plasma concentrations regardless of dose, route, or duration of dosing. Breastfeeding In patients with bronchiectasis, sputum concentrations of fluconazole following a single 150 mg oral dose were equal to plasma concentrations at both 4 and 24 hours post dose. Clinical and mycological response rates were higher in the children treated with fluconazole.Clinical cure at the end of treatment was reported for 86% of fluconazole-treated patients compared to 46% of nystatin treated patients. After the loading dose, the daily dose (according to indication) should be based on the following table:Patients on hemodialysis should receive 100% of the recommended dose after each hemodialysis; on non-dialysis days, patients should receive a reduced dose according to their creatinine clearance.These are suggested dose adjustments based on pharmacokinetics following administration of multiple doses. This combination may be used but the incidence of CNS related undesirable effects should be borne in mind.Avoid concomitant administration of voriconazole and fluconazole. Fluconazole, the first of a new subclass of synthetic triazole antifungal agents, is available as a sterile solution for intravenous use in flexible plastic containers.Fluconazole is designated chemically as 2,4-difluoro-α,αFluconazole is a white crystalline solid which is slightly soluble in water and saline.Fluconazole in Dextrose Injection, USP is an iso-osmotic, sterile, nonpyrogenic solution of fluconazole in a dextrose diluent. (See Combination therapy with cyclophosphamide and fluconazole results in an increase in serum bilirubin and serum creatinine. Therapy may be instituted before the results of the cultures and other laboratory studies are known; however, once these results become available, anti-infective therapy should be adjusted accordingly.In a multicenter study comparing fluconazole (200 mg/day) to amphotericin B (0.3 mg/kg/day) for treatment of cryptococcal meningitis in patients with AIDS, a multivariate analysis revealed three pretreatment factors that predicted death during the course of therapy: abnormal mental status, cerebrospinal fluid cryptococcal antigen titer greater than 1:1024, and cerebrospinal fluid white blood cell count of less than 20 cells/mmAn open-label, comparative study of the efficacy and safety of fluconazole (2 to 3 mg/kg/day) and oral nystatin (400,000 I.U. There were no fetal effects at 5 mg/kg or 10 mg/kg; increases in fetal anatomical variants (supernumerary ribs, renal pelvis dilation) and delays in ossification were observed at 25 mg/kg and 50 mg/kg and higher doses. [See USP Controlled Room Temperature.] There was no significant pharmacokinetic interaction between fluconazole and azithromycin.Certain calcium channel antagonists (nifedipine, isradipine, amlodipine, verapamil, and felodipine) are metabolized by CYP3A4. In cases of fluconazole-associated hepatotoxicity, no obvious relationship to total daily dose, duration of therapy, sex, or age of the patient has been observed. Thus, multiple-dose use of fluconazole at these doses is unlikely to have an effect on the efficacy of the combined oral contraceptive.Clinically significant hypoglycemia may be precipitated by the use of fluconazole with oral hypoglycemic agents; one fatality has been reported from hypoglycemia in association with combined fluconazole and glyburide use. Of serum theophylline concentrations in patients with severe hepatic impairment ( Child-Pugh Class C ) increased! 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