It's much more effective for me on an empty stomach. Even with the Glycopyrrolate a good cup of coffee can cause sweating to return. I forgot to take it one day before a busy shift (I work retail) and i was dripping sweat all day, trying to avoid people, it literally ruined my whole day. I’ve always been a sweater in anxious social situations, but now I’m wondering if the Sudafed is making it worse. And the side effects are nothing to be dismissed so easily. According to the Mayo Clinic, oral glycopyrrolate works well for sweating because it blocks the nerve impulses to the sweat glands. Drinking lots of water is not as effective as wetting your skin. !I have noticed more than a few people saying that glycopyrrolate stopped working for them after a period of time. However, 2mg has reduced my sweating enough that I now feel For example, if I find myself in a stressful situation, my hands might sweat at 75% 'wetness'. When other remedies fail to work, this medication may just be the answer.I have been taking Robinul (Glycopporyate) for two years. Even with the Glycopyrrolate a good cup of coffee can cause sweating to return. The FDA has approved glycopyrrolate oral solution for the treatment of patients aged 3 to 16 years with chronic severe drooling associated with neurologic conditions, such as cerebral palsy. It started with puberty as for many of us, I guess. Interestingly, researchers found that donepezil taken at night increased nightmares, but a morning dose had no such effect. Gylco helps all over the body so might help you!New comments cannot be posted and votes cannot be castPress J to jump to the feed. Almost like my hands are trying to sweat and can't so they get swollen. They unfortunately told me they could only treat under arms. I've since moved and just told my new doc I take Glycopyrrolate and they re-prescribed it without issue. I quit my job -- yes $1M -- and stayed in Florida on a water house for six years as a depressed man who once had everything and had dinner with congressman and that made me feel different. When first prescribed play with the dosage, maybe start with 1 mg on an empty stomach and wait several hours before increasing. @pleonasm - Honestly, I would have just got a second opinion if I were your friend. Posted In: Hyperhidrosis Surgery Forum Guest Jack May on June 14, 2017 at 6:07 am #4875 hey guys, What has worked better for you, the oral version or topical version of Glycopyrrolate? But he was a martial artist and having slippery hands and feet was actually pretty dangerous. I am the one who wrote about hyperhydrosis. I’m on intermittent fasting, so I don’t eat breakfast. 13. To cut down on the amount of glyco threads let's pool our information for people who are trying to get it prescribed or have just got it and are full of questions. you might be completely fine, so see what works best for you.I will now try to find a regimen that I can take at night, so that the dryness begins first thing in the morning rather than at 12 noon.One thing I forgot to mention in my previous post - of course, reduced sweating could make you overheat in hot weather or during exercise - be careful! Currently I take 1mg on an as-needed basis and I've seen no change in effectiveness, but it may be because I'm not taking it daily.Thanks! I actually use them to suppress facial flushing (they’re also vasoconstrictors) that I get when I teach class, but I also sweat heavily, to the point where I can’t lift up my arms to write on the board. I'll post my findings in a separate post after about a week.Yeah, so 15-30 mins is definitely quite close to your mealtime. Even with the Glycopyrrolate a good cup of coffee can cause sweating to return. In the end, I think he tried to get this kind of treatment and the doctor refused to let him use it because he didn't think the problem was severe enough to warrant the medicine.