Similarly, in the manual chart reviews of patients with chronic hypernatremia, no patients experienced worsening mental status, seizures, or generalized cerebral edema due to correction of serum sodium. The body will respond by either increasing thirst (to boost water intake) or passing a greater amount of sodium in the urine (to excrete more sodium).Hypernatremia may not cause any symptoms, meaning that a person may not be aware that they have it. We also segregated patients into those that presented with severe hypernatremia on admission (In the admission hypernatremia group, those with a rapid correction had a higher proportion of female patients (75% versus 47%; Although patients in the hospital-acquired hypernatremia group who experienced rapid correction had no difference in sex or CKD status, they had a shorter median length of stay (4 days [interquartile range (IQR), 2.2–8.8] versus 7 days [IQR 3.1–14.7]; There were some missing values for first care unit, marital status, and laboratory values at the time of peak sodium level, but they were used only for descriptive purposes.In the rapid serum sodium correction group of patients with hospital-acquired hypernatremia, the time to correction to serum sodium <145 from peak serum sodium was 14.7 hours (IQR, 9.2–18.9). Finally, we accounted for many factors (including comorbidity burden and DNR status) that may confound the association between hypernatremia correction and mortality.These results, however, should be interpreted in light of some limitations. Hypernatremia, is a high concentration of sodium in the blood.Normal serum sodium levels are 135 – 145 mmol/L (135 – 145 mEq/L). Certain people are more at risk than others of developing hypernatremia, including people in long-term care facilities and older people. Often, a person will not realize that they have the condition until their doctor examines them or runs a blood or urine test.When a doctor diagnoses and treats hypernatremia early, the outlook for people with this condition is generally good. In general, the ratio of brain volume to cranial vault size was greatest around age 6 years. In rare cases, consuming too much sodium can cause hypernatremia to occur.Sodium is an electrolyte that plays an essential role in regulating the levels of water and other substances in the body. We used the Wilcoxon rank sum test for continuous variables and the Fisher exact test for categorical variables. Background and objectives Hypernatremia is common in hospitalized, critically ill patients. Dr. Van Vleck reports personal fees from Clinithink, outside the submitted work. An adjustment of age, sex, DNR status, and Charlson comorbidity index was included in the model. The median rate of correction was higher in patients with hospital-acquired hypernatremia (0.9; IQR, 0.6–1.6 mmol/L per hour) compared with those with admission hypernatremia (0.7; IQR, 0.6–1.4) (Distribution of the sodium level, difference, and correction time of adults admitted to ICU with hypernatremia at admission and hospital-acquiredThe in-hospital mortality proportion was not significantly different between patients with admission hypernatremia with rapid correction versus slow correction (25% versus 28%; Measures of association and 95% CIs for overall correction rate and at 24 hours with the mortality outcomeThe Kaplan–Meier curves for 30-day survival for the rapid versus slow correction rate groups are shown in Incidence of in-hospital mortality by rapid versus slow correction rates by different cut-offs (>8, >10, and >12 mmol/L in 24 hours) for both groups of patients are presented in In subgroup analyses, the mortality rates in admission and hospital-acquired hypernatremia groups were not significantly different among sex and age (by median) categories (≤69 versus >69 years) in both slower and rapid correction groups (We conducted a manual chart review of all available imaging reports, physician progress notes, and discharge summaries among the admission hypernatremia group and found no patients that had documented worsening mental status, seizures, or generalized cerebral edema due to correction of serum sodium. We calculated rate of serum sodium correction was calculated using the following formula:Rapid hypernatremia correction was defined as an overall serum sodium correction rate of >0.5 and ≤0.5 mmol/L per hour was considered slower hypernatremia correction rate. At-risk populations In most cases, an underlying health condition, such as kidney disease or diabetes, will cause a person’s hypernatremia.