Indometacin Capsules BP 25mg - Patient Information Leaflet (PIL) by Accord-UK Ltd INDOMETACIN CAPSULES BP 50mg. • Anticoagulants: NSAIDs may enhance the effects of anti-coagulants, such as warfarin (see section 4.4). Taking it again could be fatal.Combining this drug with alcohol may increase your risk of bleeding in your stomach or intestines. • Other analgesics including cyclooxygenase-2 selective inhibitors: Avoid concomitant use of two or more NSAIDs (including aspirin) as this may increase the risk of adverse effects (see section 4.4). All rights reserved. It should be used cautiously in patients with existing but controlled infection. In women who have difficulties conceiving or who are undergoing investigation of infertility, withdrawal of indometacin should be considered. misoprostol or proton pump inhibitors) should be considered for these patients, and also for patients requiring concomitant low dose aspirin, or other drugs likely to increase gastrointestinal risk (see below and section 4.5). That way, a pharmacist can check for possible drug interactions.Examples of drugs that can cause interactions with indomethacin oral capsule are listed below.These drugs may not work as well to control blood pressure when taken with indomethacin.Combining these medications increases your risk of stomach problems, including ulcers and bleeding.Combining these drugs may cause lithium to take longer to be clear from your body. Indomethacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.If you’re over 65 years of age, you may have more side effects, such as bleeding in the stomach or intestines. • Cardiac glycosides: NSAIDs may exacerbate cardiac failure, reduce GFR and increase plasma-cardiac glycoside levels. If experienced, these tend to have a Severe expression 1. Store below 30°C.Do not use Indometacin after the expiry date, which is shown on the label or carton. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. The administration of an NSAID may cause a dose dependent reduction in prostaglandin formation and precipitate renal failure. Frequent or prolonged convulsions should be treated with intravenous diazepam. In patients with renal, cardiac, hepatic impairment, hypertension, heart failure or conditions predisposing to fluid retention caution is required since the use of NSAIDs may result in deterioration of renal function (see section 4.8). They usually disappear on reducing the dosage; if not, the risks of continuing therapy should be weighed against the possible benefits. This increases the level of lithium in your body, which may cause nausea, tremors, and dizziness.Indomethacin may increase the amount of methotrexate in your body to toxic levels. Mild side effects may disappear within a few days or a couple of weeks. In patients with systemic lupus erythematosus (SLE) and mixed connective tissue disorders there may be an increased risk of aseptic meningitis (see section 4.8). Our website services, content, and products are for informational purposes only. Risk of indometacin toxicity with ritonavir, avoid concomitant use. By continuing to browse the site you are agreeing to our policy on the use of cookies. If affected, do not drive or operate machinery.Indometacin may alter the results of some blood or urine tests. Renal and liver function should be closely monitored. Abnormal Liver Function Tests 2. • Patients should be periodically observed to allow early detection of any unwanted effects on peripheral blood (anaemia), liver function (see section 4.8), or gastrointestinal tract especially during prolonged therapy.After long term treatment with analgesics, headache may develop or aggravate. Indomethacin is a non-steroidal anti-inflammatory indole derivative designated chemically as 1 … Blocking the enzyme helps to reduce inflammation and pain.Indomethacin oral capsule may cause drowsiness. Combination therapy with protective agents (e.g. Taking it again could be fatal.Combining this drug with alcohol may increase your risk of bleeding in your stomach or intestines. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 911.Indomethacin oral capsule can interact with other medications, herbs, or vitamins you might be taking. Gout Oral Conventional capsules: 50 mg 3 times daily until pain is tolerable; then reduce dosage rapidly and discontinue.