A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. indomethacin; n. an anti inflammatory drug (see NSAID), used mainly for the relief of pain and severe inflammation in the treatment of rheumatic disease and similar disorders. Click on a plot to see the median, interquartile range, low and high data points. Indomethacin is a synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. Indomethacin has also been used clinically to delay premature labor, reduce Indomethacin is a potent drug with many serious side effects and should not be considered an analgesic for minor aches and pains or fever. The present and future of tocolysis". Periodic serum electrolyte (sodium, potassium, chloride) measurements, complete blood cell counts and assessment of liver enzymes as well as of creatinine (renal function) should be performed. For other types of ligands, e.g. Trade names:… (indomethacin) n. an anti inflammatory drug (see NSAID), used in the treatment of arthritic conditions. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. Properties were generated using the CDK toolkit. highly dosed antacids, Additionally, indomethacin quite often causes headache (10 to 20%), sometimes with vertigo and dizziness, hearing loss, tinnitus, blurred vision (with or without retinal damage). The drug is more potent than Indomethacin has two additional modes of actions with clinical importance:These additional effects account as well for the analgesic and the anti-inflammatory properties.Since indomethacin inhibits both COX-1 and COX-2, it inhibits the production of prostaglandins in the To reduce the possibility of peptic ulcers, indomethacin should be prescribed at the lowest dosage needed to achieve a therapeutic effect, usually between 50–200 mg/day. In|do|me|ta|cin [Kunstw. 4.4 out of 5 stars Date First Available 15 Oct. 2008 Seller Information Blood pressure checks will reveal development of hypertension. ASIN B001IC5TLE Customer Reviews: 4.4 out of 5 stars 1,267 ratings. A value of zero indicates that no data are available. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.Calculated molecular properties are available for small molecules and natural products (not peptides). Ferreira S, Moncada S, Vane J (Jun 23 1971). For more info on each category see the Product supplier links are provided as a service to assist in identifying commercial suppliers of reagents that are mentioned on the IUPHAR/BPS Guide to PHARMACOLOGY database website, and do not imply their endorsement by NC-IUPHAR.Links are provided in return for sponsorship, used to fund improvements to this database. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. If you are interested in sponsoring the database, please Cases of life-threatening shock (including The frequency and severity of side effects and the availability of better tolerated alternatives make indomethacin today a drug of second choice. Exact human data does not exist, but some fatal human cases, particularly in children and adolescents, have been seen.Generally, overdose in humans causes drowsiness, dizziness, severe headache, mental confusion, The treatment is symptomatic and largely the same as with The risk of overdose after exaggerated local treatment with gel or spray is very limited.We are using cookies for the best presentation of our site.