Consider a visit with your healthcare provider for a pre-pregnancy checkup before you stop taking the pill.Your periods may be lighter and shorter than usual. Each blister card contains 28 tablets in the following order:Do not prescribe Tri-Lo-Sprintec to women who are known to have the following conditions:Do not use Tri-Lo-Sprintec in women with liver disease, such as acute viral hepatitis or severe (decompensated) cirrhosis of liver Tri-Lo-Sprintec is contraindicated in women with benign and malignant liver tumors Studies have shown an increased risk of developing hepatocellular carcinoma in long-term (>8 years) COC users. If the patient has adhered to the prescribed regimen and misses two consecutive periods, rule out pregnancy.Extensive epidemiological studies have revealed no increased risk of birth defects in women who have used oral contraceptives prior to pregnancy. The box on the bottom of the chart shows the chance of getting pregnant for women who do not use birth control and are trying to get pregnant.Tri-Lo-Sprintec may affect the way other medicines work, and other medicines may affect how well Tri-Lo-Sprintec works.Know the medicines you take. 2. Combination Pill. COCs can reduce milk production in breastfeeding mothers. $20/month or free with most insurance. Each box on the chart contains a list of birth control methods that are similar in effectiveness. Tri-Lo-Sprintec is dispensed in a blister pack tablet dispenser [see How Supplied/Storage and Handling (16)]. Irregular vaginal bleeding or spotting may happen while you are taking Tri-Lo-Sprintec, especially during the first few months of use. Brand. National Library of Medicine, research has shown that the hormone combination in Ortho Tri-Cyclen Lo tends to be well-tolerated by most women. The amount of progestin in Ortho Tri-Cyclen Lo slowly increases each week of the pill pack, but the amount of estrogen stays the same. Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Tri-Lo-Sprintec ® (norgestimate and ethinyl estradiol tablets) is indicated for use by females of reproductive potential to prevent pregnancy [see Clinical Studies (14)].. Tri-Lo-Sprintec Dosage and Administration How to Start Tri-Lo-Sprintec. NGM is rapidly and completely metabolized by first pass (intestinal and/or hepatic) mechanisms to norelgestromin (NGMN) and norgestrel (NG), which are the major active metabolites of NGM.Mean pharmacokinetic parameters for NGMN, NG and EE during three cycles of administration of Tri-Lo-Sprintec are summarized in Table 3.Peak serum concentrations of NGMN and EE were generally reached by 2 hours after administration of Tri-Lo-Sprintec. Discontinue Tri-Lo-Sprintec use if pregnancy is confirmed.Administration of COCs to induce withdrawal bleeding should not be used as a test for pregnancy Carefully observe women with a history of depression and discontinue Tri-Lo-Sprintec if depression recurs to a serious degree.The estrogen component of COCs may raise the serum concentrations of thyroxine-binding globulin, sex hormone-binding globulin, and cortisol-binding globulin. 2 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80 and titanium dioxide.White pills: anhydrous lactose, hypromellose, magnesium stearate, and microcrystalline cellulose.There are two ways to start taking birth control pills, Sunday Start or Day 1 Start. The following is a good rule of thumb to follow Accumulation following multiple dosing of the 0.180 mg NGM / 0.025 mg EE dose is approximately 1.5 to 2 fold for NGMN and approximately 1.5 fold for EE compared with single dose administration, in agreement with that predicted based on linear kinetics of NGMN and EE. NGM’s primary active metabolite is NGMN. In a study of 1,723 women who used this birth control pill, only 4% (69 women) stopped using Ortho Tri-Cyclen Lo because of its side effects. It appears that the price for Ortho Tri-Cyclen Lo ranges between $45-$140 per one pack of pills. Counsel women to use an alternative method of contraception or a back-up method when enzyme inducers are used with COCs, and to continue back-up contraception for 28 days after discontinuing the enzyme inducer to ensure contraceptive reliability.Co-administration of atorvastatin or rosuvastatin and certain COCs containing EE increase AUC values for EE by approximately 20 to 25%.