If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Follow your doctor's orders or the directions on the label. Ledipasvir / sofosbuvir systemic 90 mg / 400 mg (ASE 9875) If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Other side effects not listed may also occur in some patients. For non-prescription products, read the label or package ingredients carefully.Appropriate studies have not been performed on the relationship of age to the effects of ledipasvir and sofosbuvir combination in children younger than 3 years of age. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Although not all of these side effects may occur, if they do occur they may need medical attention.Some side effects of ledipasvir / sofosbuvir may occur that usually Check with your health care professional if any of the following side effects The most common side effects reported with this drug were fatigue, headache, asthenia, and nausea. Along with its needed effects, a medicine may cause some unwanted effects. FDA. You may report side effects to FDA at 1-800-FDA-1088. LEDIPASVIR; SOFOSBUVIR (led' i pas' vir; soe fos' bue vir) is two antiviral medicines in one tablet. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Increased lipase (greater than 3 x ULN) was reported in 1%, 3%, and 9% of patients with compensated cirrhosis using placebo, this drug plus ribavirin for 12 weeks, and this drug for 24 weeks, respectively. Make sure you tell your doctor if you have any other medical problems, especially:Ledipasvir and sofosbuvir should come with a patient information leaflet. If you notice any other effects, check with your healthcare professional.Call your doctor for medical advice about side effects. The most common side effects reported with this drug were fatigue, headache, asthenia, and nausea. This is not a complete list of side effects and others may occur. These side effects may go away during treatment as your body adjusts to the medicine. Lipase elevation was transient and asymptomatic.-Frequency not reported: Depression, suicidal ideation, suicideIncreased bilirubin (greater than 1.5 x ULN) was reported in 3%, less than 1%, and 2% of patients using this drug for 8, 12, and 24 weeks, respectively. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. O 04. Read and follow the information carefully. HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV direct acting antivirals and were not receiving HBV antiviral therapy. Increased bilirubin (greater than 1.5 x ULN) was reported in 3%, 11%, and 3% of patients with compensated cirrhosis using placebo, this drug plus ribavirin for 12 weeks, and this drug for 24 weeks, respectively.Severe bradycardia and heart block have been reported when this drug was used with Serious symptomatic bradycardia has been reported in patients taking amiodarone who started therapy with this drug.1. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Do not double doses.Do not keep outdated medicine or medicine no longer needed.Ask your healthcare professional how you should dispose of any medicine you do not use.Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.