Lozol® (indapamide) is an oral antihypertensive/diuretic. Levofloxacin a fluoroquinolone antibiotic that is prescribed to treat various infections caused by bacteria. Given the small numbers observed, the significance of this finding cannot be determined statistically. When used to prepare two 250 mg doses from the 20 mL vial containing 500 mg of Levofloxacin, the full content of the vial should be withdrawn at once using a single-entry procedure, and a second dose should be prepared and stored for subsequent use [see Stability of Levofloxacin Injection Following Dilution].Prepare the desired dosage of Levofloxacin according to the table below:For example, to prepare a 500 mg dose using the 20 mL vial (25 mg/mL), withdraw 20 mL and dilute with a compatible intravenous solution to a total volume of 100 mL.This intravenous drug product should be inspected visually for particulate matter prior to administration. Three-month old beagle dogs dosed orally with Levofloxacin at 40 mg/kg/day exhibited clinically severe arthrotoxicity resulting in the termination of dosing at Day 8 of a 14-day dosing routine. * Due to the designated pathogens [see Indications and Usage (1)]. Similarly, no apparent effect of warfarin on Levofloxacin absorption and disposition was observed. Clinical success rates (defined as complete or partial resolution of the pre-treatment signs and symptoms of ABS to such an extent that no further antibiotic treatment was deemed necessary) in the microbiologically evaluable population were 91.4% (139/152) in the Levofloxacin 750 mg group and 88.6% (132/149) in the Levofloxacin 500 mg group at the test-of-cure (TOC) visit (95% CI [-4.2, 10.0] for Levofloxacin 750 mg minus Levofloxacin 500 mg). It’s a type of drug called a fluoroquinolone antibiotic. For both studies, the clinical success rate in patients with atypical pneumonia due to Chlamydophila pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila were 96%, 96%, and 70%, respectively. What should i do now? Therefore, careful monitoring of blood glucose is recommended when these agents are coadministered [see Warnings and Precautions (5.12); Adverse Reactions (6.2), Patient Counseling Information (17)].The concomitant administration of a non-steroidal anti-inflammatory drug with a fluoroquinolone, including Levofloxacin, may increase the risk of CNS stimulation and convulsive seizures [see Warnings and Precautions (5.4)].No significant effect of Levofloxacin on the plasma concentrations, AUC, and other disposition parameters for theophylline was detected in a clinical study involving healthy volunteers. Changes in sensation and possible nerve damage (Peripheral Neuropathy)4. Patients were treated with Levofloxacin for a wide variety of infectious diseases [see Indications and Usage (1)]. Some reactions have been accompanied by cardiovascular collapse, hypotension/shock, seizure, loss of consciousness, tingling, angioedema (including tongue, laryngeal, throat, or facial edema/swelling), airway obstruction (including bronchospasm, shortness of breath, and acute respiratory distress), dyspnea, urticaria, itching, and other serious skin reactions. The patient should be observed and appropriate hydration maintained. Clinical success rates (cure plus improvement) in the clinically evaluable population were 90.9% in the Levofloxacin 750 mg group and 91.1% in the Levofloxacin 500 mg group. Therefore, no dosage adjustment for Levofloxacin or digoxin is required when administered concomitantly.No significant effect of probenecid or cimetidine on the Cmax of Levofloxacin was observed in a clinical study involving healthy volunteers. Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug. Levofloxacin has not been tested in humans for the post-exposure prevention of inhalation anthrax. Therefore, no dosage adjustment is required for Levofloxacin or cyclosporine when administered concomitantly.No significant effect of Levofloxacin on the peak plasma concentrations, AUC, and other disposition parameters for digoxin was detected in a clinical study involving healthy volunteers. Dermal Levofloxacin concentrations in the hairless mice ranged from 25 to 42 mcg/g at the highest Levofloxacin dose level (300 mg/kg/day) used in the photo-carcinogenicity study. Levofloxacin has not been tested in humans for the post-exposure prevention of inhalation anthrax. Levofloxacin should be avoided in patients with known prolongation of the QT interval, patients with uncorrected hypokalemia, and patients receiving Class IA (quinidine, procainamide), or Class III (amiodarone, sotalol) antiarrhythmic agents.