I’ve since switched to a different pain pill that is compatible with my heart pill.Kudos to you for going out of your way to manage your Collie’s health, and good luck as you continue to search for what will work best for her!Thanks for reply. The tail curling and pacing lasted over a week. Additionally, it will enable you to discuss the pros and cons of Atopica use.While cyclosporine use is relatively safe, it is necessary to be extra cautious when using this drug. A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. Thanks for your efforts to help!Your comment made me realize I might need to add another paragraph or two about Credelio… Credelio was actually recommended to me by both of my dogs’ veterinarians. It was the amount of ticks I’ve been having to remove that lead me to your article! Still, if you live in the city and don’t walk your dogs through long grass or woodsy areas, this could be a great choice for you.Sentinel comes in a chewable pill form and protects against multiple internal parasites (heartworms, whipworms, hookworms, and roundworms) as well as the development of flea eggs. The Whole Dog Journal notes that “Ivermectin has the most potential for toxicity.”There are other risks involving Ivermectin. Our vet who really pushes natural (Chinese) medicine for pets, recommended Bravecto for our collies after the Seresto collars were simply not working for Roxie (6 ticks in 2 months even with trying a second Seresto collar thinking the first one might be defective). He said Elanco is very conscientious about safety (particularly since Interceptor is used by so many people who have MDR1-prone dogs), and even with his advice I still stood there reading the label and agonizing over my decision before I decided to give it a try! I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. The complete list of all drugs that may interact with cyclosporine is available at your veterinarians office.The list below highlights a few of the drugs that interact with Atopica. So the following month we tried Interceptor Plus and it was fine. Positive feedback keeps me writing! Most veterinarians in my area are still prescribing Bravecto, simply because they aren’t yet comfortable enough with Credelio. It’s in lots of grain-based foods because lots of grains are stored with diatomaceous earth to keep the bugs from eating the grain.”The best thing about Seresto is how long it can do its job – up to 8 months! I interviewed a few people (rescue workers, owners, and breeders) from that group for Thank you for fostering! We can eat it. Happy to help! Roxie has never been tested, but she is Dash’s niece so probably also mutant/normal if I were to guess.According to Dr. Jean Dodds of Hemopet, “…researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning.” In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. If Barnicals has taken each of these medications in the past and not had any issues with them, then they can be given together. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. Dash is MDR1 mutant/normal. You went and bought the best flea medication and applied it to your dog, just like you were supposed to. The article mentioned Seresto covered 4 kinds of ticks, so I’m glad you clarified your selection for me. On the second dose she went into an extreme “false heat.” This was shown by panting , pacing, and curling her tail to show being receptive for breeding. Veterinarians have the legal right to prescribe drugs like Atopica for purposes beyond those for which they have been approved. Anyway, we have a lot of lyme disease here in Wisconsin so we need a good tick preventative. The Seresto collar seemed to work reasonably well for Dash, but even so we occasionally would find a tick on him. I just took her off Sentinel Flavor Tabs. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive.Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Really do not think there is a synthetic of Pyrethrin, which is a flavored chewable, and it fine. For which they have been approved girl and she had a sensitive stomach, but also tired of my! 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