Human data regarding teratogenicity after maternal use of amantadine is scarce. Seizures may be exacerbated in patients with prior history of seizure disorders. Amantadine is approximately 67% bound to plasma proteins over a concentration range of 0.1 to 2.0 μg/mL. The mean ± SD maximum plasma concentration was 0.22 ± 0.03μg/mL (range: 0.18 to 0.32 μg/mL). However, in two non-GLP studies in rats in which females were dosed from 5 days prior to mating to Day 6 of gestation or on Days 7-14 of gestation, Symmetrel produced increases in embryonic death at an oral dose of 100 mg/kg (or 3 times the maximum recommended human dose on a mg/m2 basis).
Cardiac dysfunction includes arrhythmia, tachycardia and hypertension (see Suicide attempts, some of which have been fatal, have been reported in patients treated with Symmetrel, many of whom received short courses for influenza treatment or prophylaxis. BRAND NAME(S): Symmetrel. Bird flu (avian flu, avian influenza) infection in humans may result from contact with infected poultry. After one to several weeks at 100 mg once daily, the dose may be increased to 100 mg twice daily, if necessary.Occasionally, patients whose responses are not optimal with Symmetrel at 200 mg daily may benefit from an increase up to 400 mg daily in divided doses. Thus, the dose of Symmetrel should be reduced in patients with renal impairment and in individuals who are 65 years of age or older (see Care should be exercised when administering Symmetrel to patients with liver disease. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep … Look up information about prescription drugs, over-the-counter medications, herbs, vitamins and supplements. The 100 mg dose is recommended for persons who have demonstrated intolerance to 200 mg of Symmetrel daily because of CNS or other toxicities.Prophylactic dosing should be started in anticipation of an influenza A outbreak and before or after contact with individuals with influenza A virus respiratory tract illness.Symmetrel should be continued daily for at least 10 days following a known exposure. If you have been infected with the flu, this medication may help make your symptoms less severe and shorten the time it will take you to get better.
When inactivated influenza A virus vaccine is unavailable or contraindicated, Symmetrel should be administered for the duration of known influenza A in the community because of repeated and unknown exposure.Treatment of influenza A virus illness should be started as soon as possible, preferably within 24 to 48 hours after onset of signs and symptoms, and should be continued for 24 to 48 hours after the disappearance of signs and symptoms.The usual dose of Symmetrel is 100 mg twice a day when used alone. We comply with the HONcode standard for trustworthy health information - Symmetrel (Amantadine Hydrochloride, USP) is designated generically as amantadine hydrochloride and chemically as 1-adamantanamine hydrochloride.Amantadine hydrochloride is a stable white or nearly white crystalline powder, freely soluble in water and soluble in alcohol and in chloroform.Amantadine hydrochloride has pharmacological actions as both an an… Get facts about the types of drug interactions, what substances or other things that may interact with drugs such as OTC drug and prescription drugs, vitamins, food(s) (grapefruit), and laboratory tests. Antihistamine for allergies and hay fever: Low molecular weight heparins, enoxaparin and dalteparin (Lovenox and Fragmin) Anticoagulants: Magnesium sulfate: Used to treat preeclampsia and eclampsia; may reduce milk supply: Methylergonovine (short courses) (Methergine) Used to prevent or control bleeding after childbirth: Metoprolol (Lopressor) Keep the bottle tightly closed when not in use.Take the missed dose as soon as you remember. However, it has not been demonstrated that a 100 mg daily dose is as effective as a 200 mg daily dose for prophylaxis, nor has the 100 mg daily dose been studied in the treatment of acute influenza illness. Rimantadine is a closely related adamantane derivative with similar biological properties; both target the M2 … Symptoms of MS
Amantadine/Amantadine Hydrochloride/Symmetrel Oral Cap: 100mg Amantadine/Amantadine Hydrochloride/Symmetrel Oral Sol: 5mL, 50mg Amantadine/Amantadine Hydrochloride/Symmetrel Oral Tab: 100mg GOCOVRI Oral Cap ER: 68.5mg, 137mg OSMOLEX ER Oral Tab ER: 129mg, 193mg, 258mg. Whether these changes are due to decline in renal function or other age related factors is not known.In a study of young healthy subjects (n=20), mean renal clearance of amantadine, normalized for body mass index, was 1.5 fold higher in males compared to females (p<0.032).Compared with otherwise healthy adult individuals, the clearance of amantadine is significantly reduced in adult patients with renal insufficiency.
Pulmonary edema and respiratory distress (including adult respiratory distress syndrome - ARDS) have been reported; renal dysfunction including increased BUN, decreased creatinine clearance and renal insufficiency can occur.