I never really shook off the sedative effect though which was the … I'm wondering if this is a side effect that will go away or if the 22.5 is too much for me. It's an uncomfortable feeling to say the least. Advertising revenue supports our not-for-profit mission.Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. 0. Missed Dose . After about 7 months I felt as though I was feeling down again and back to not sleeping. So I'm now on 45mg which seems to be ok for me and I didn't notice any difference in regard to being extra tired or anything. Select one or more newsletters to continue. I know my depression has been really bad and thats why i increased my dosage,but to have the extra anxiety to go along with it is not my cup of tea.Hello I've been trying to consider my answer before I posted back. I found that it took weeks to months for this to make a significant difference for my depression and anxiety and having tried many medicines over the years I had to persevere with it along with CBT and therapy. I'm stuck between a rock and a hard place so to speak.You need to be a member in order to leave a commentSign up for a new account in our community. The effect it had on me over time has been to make me more calm and relaxed. Anyway enough about me,have you upped your dose from 15-30mg? Starting taking Mirtazapine 15 mg 3 weeks ago. %��������� I was on 15mg for a few weeks with a view to have it upped to 30mg. Please post comments regarding your status at 30!I really wanted to have some answers as far as moving up to 30mg and finding out whether it's helping me with my depression /sleep,only i've been standing still for quite sometime and unable to move due to my fears and depression. If your dose is different, do not change it unless your doctor tells you to do so.The amount of medicine that you take depends on the strength of the medicine. I was on 15mg for a few weeks with a view to have it upped to 30mg. Mirapex rated 7.3/10 vs Pramipexole rated 6.9/10 in overall patient satisfaction. Try and go into an increased dosage with a positive mindset as I think there is alot to the power of the brain in helping you have better reaction to the medication in other words dont be frizzled, instead be positive and upbeat that this is going to work and your mind will help this to come true.I wish you the best of luck, sorry I dont have an answer for you but I do think the doctors advice is sound and you will do okay...I quickly got used to 15mg then 30mg. Last night i took the 22.5 mg dose and it didn't have the same effect as the night before. You'll usually take mirtazapine once a day. After about 7 months I felt as though I was feeling down again and back to not sleeping. Read and follow these instructions carefully. That would be adding another night time medicine and i'm not sure I want to go that route yet. Children—Use and dose must be determined by your doctor. What I like to think is this could be the thing that helps me. %PDF-1.3 Hello, I have been on 30mg of mirtazapine for a month and it is pooping out because I am crying and feeling low again. I know its scary trying different medicines and you don't know what the outcome is going to be when changing the drug or dosage. My gp didn't want to up the dose because I had restless arms, knee joint pains dizziness and chest pain in the first week of upping from 15-30mg… Ask your doctor if you have any questions. The first night I got a little extra grogginess but not to much more than usual and fell asleep fast.I had a little dizziness and fog in the morning but it only lasted maybe an hour( if that.) It was like i didn't take the 22.5mg. Your doctor may adjust your dose if needed. I also take it in the afternoon (smaller dose),but again only when i just can't stand the anxiety any longer. I guess that means i'm tolerating it pretty well although it took me an hour to fall asleep. Maybe 22.5 isn't enough? My depression on the other hand is increasing as I feel quite "medicated" and unable to feel motivated or have desire for the next day....and ofcourse best of luck to the thread starter!! 1. mirtazapine and exhaustion . The first night I got a little extra grogginess but not to much more than usual and fell asleep fast.I had a little dizziness and fog in the morning but it only lasted maybe an hour( if that.) The first night I got a little extra grogginess but not to much more than usual and fell asleep fast.I had a little dizziness and fog in the morning but it only lasted maybe an hour( if that.) All rights reserved. It was like i didn't take the 22.5mg. I also take 1 mg Lorazepam at night before bed. I think your doctor is doing a good thing bumping you up to 30 mg since you dont seem to be showing enough improvement. Mirtazapine is an antidepressant medicine. Ive had SOME good days and my sleep HAS improved but im having more and more bad days as I go on .