Disclaimer: These citations have been automatically generated based on the information we have and it may not be 100% accurate. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Get Free Access Through Your Institution A case of Schamberg's disease responding dramatically to PUVA treatment. Granulomatous variant of pigmented purpuric dermatosis: report of two cases and review of the literature. Magro CM, Schaefer JT, Crowson AN, Li J, Morrison C. Pigmented purpuric dermatosis: classification by phenotypic and molecular profiles. Purpuric generalized lichen nitidus: an unusual eruption simulating pigmented purpuric dermatosis. Bowel obstructions can be fatal if left untreated. Mycosis fungoides presenting as pigmented purpuric dermatitis. /viewarticle/934935 /viewarticle/936693 2010 If you log out, you will be required to enter your username and password the next time you visit. The purple spots of purpura are fairly easy to tell apart from other rashes. 1108312-overview Please confirm that you would like to log out of Medscape. Puddu P, Ferranti G, Frezzolini A, et al. Henoch-Schonlein purpura can also cause abdominal pain and aching joints. Successful treatment of pigmented purpuric dermatosis with griseofulvin. MNT is the registered trade mark of Healthline Media. Purpura tends to occur in clusters that are found in a single area or cover a large portion of the body. #### What you need to know Bleeding into the skin or mucosa from small vessels produces a purpuric rash, or smaller petechiae (1-2 mm in diameter). Viral … The purpura are usually 2-10 mm in diameter and are distributed over the buttocks and legs, as shown. 2002 Quick diagnosis and treatment of the underlying cause can reduce a patient’s risk of serious complications. Amiodarone is an iodinated benzofuran derivative that is used to suppress ventricular and supraventricular tachyarrhythmias. A report of two cases of pigmented purpuric dermatoses treated with PUVA therapy. The rash can appear anywhere on the body, including on mucous membranes such as the lining of the mouth. To treat purpura, doctors must determine its cause. Patients with a petechial or purpuric eruption, fever, and altered sensorium represent a medical emergency; the differential diagnosis is listed in Box 24.1. A low platelet count can cause excessive bleeding and bruising and be caused by a number of factors, including: A range of underlying medical conditions can cause both kinds of purpura. Toro JR, Sander CA, LeBoit PE. The identification of petechiae can be done by demonstrating the absence of blanching and this can be accomplished by placing a slide over the areas and pushing down. Men are more frequently affected than women. Pulmonary toxicity is among the most serious adverse effects of amiodarone. However, finding the underlying cause of purpura can be tricky. This leaves them more at risk of the bleeding that creates purpura’s typical rash. Gkalea V, Tang S, Favier R, Kuadjovi C, Bégon E, Bugaut H, et al. Platelets are cell fragments that help blood clot more effectively, preventing dangerous bleeding. Viral … Purpura itself is a symptom rather than a condition. Some of the lesions show the characteristic orange-brown, speckled, cayenne pepper–like discoloration that is the hallmark clinical sign of a capillaritis. Early cutaneous T-cell lymphoma, purpuric clothing contact dermatitis, and drug hypersensitivity reactions should be considered in the differential diagnosis. Please consult the latest official manual style if you have any questions regarding the format accuracy.Purpura is extravasation of red blood cells into the skin or mucous membrane. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Rarely, serious kidney damage can occur.Henoch-Schonlein purpura can affect anyone, but it's most common in children between the ages of 2 and 6. Between 50% and 75% of children with meningococcemia have a purpuric or petechial rash, principally on the trunk and lower extremities (Figs 24.5, 24.6, and 24.7). A unilateral purpuric rash in the left inguinal region Several symptoms of COVID‐19 have been reported so far; including fever, fatigue, myalgia, headache, diarrhea, dry cough, and dyspnea that may lead to acute respiratory distress syndrome and death.