If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:Notes: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. The dosage or frequency of administration should only be increased on medical advice. Voltaren should be used with caution in patients with fluid retention or heart failure.NSAIDs, including Voltaren, can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine, which can be fatal. Abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes and tinnitus. In that open-label study, a higher incidence of borderline (less than 3 times the ULN), moderate (3-8 times the ULN), and marked (>8 times the ULN) elevations of ALT or AST was observed in patients receiving diclofenac when compared to other NSAIDs. However, severe hepatic reactions can occur at any time during treatment with diclofenac. Patients receiving Voltaren who may be adversely affected by alterations in platelet function, such as those with coagulation disorders or patients receiving anticoagulants, should be carefully monitored.Patients with asthma may have aspirin-sensitive asthma. per dose 2 mg), inhalation route preferred over oral route. Diclofenac is 100% absorbed after oral administration compared to IV administration as measured by urine recovery. Borderline elevations (i.e., less than 3 times the ULN [ULN = the upper limit of the normal range]) or greater elevations of transaminases occurred in about 15% of diclofenac-treated patients. For the relief of ankylosing spondylitis, the recommended dosage is 100-125 mg/day, administered as 25 mg q.i.d., with an extra 25-mg dose at bedtime if necessary. The minimum starting dose is (2mg) one 5 ml spoonful (5ml), 3 or 4 times per day. Some of these reported cases resulted in fatalities or liver transplantation. However, there is usually a delay in the onset of absorption of 1 to 4.5 hours and a reduction in peak plasma levels of <20%.The apparent volume of distribution (V/F) of diclofenac sodium is 1.4 L/kg. The chemical name is 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monosodium salt. Keep out of the reach and sight of children. Since cross-reactivity, including bronchospasm, between aspirin and other nonsteroidal anti-inflammatory drugs has been reported in such aspirin-sensitive patients, Voltaren should not be administered to patients with this form of aspirin sensitivity and should be used with caution in patients with preexisting asthma.Because serious GI tract ulcerations and bleeding can occur without warning symptoms, physicians should monitor for signs or symptoms of GI bleeding. Only one in five patients, who develop a serious upper GI adverse event on NSAID therapy, is symptomatic. Different formulations of diclofenac [VoltarenDo not store above 30ºC (86ºF). For oral administration. or if abnormal liver tests persist or worsen, Voltaren should be discontinued.Reproductive studies conducted in rats and rabbits have not demonstrated evidence of developmental abnormalities. In patients with renal dysfunction, peak concentrations of metabolites 4'-hydroxy- and 5-hydroxy-diclofenac were approximately 50% and 4% of the parent compound after single oral dosing compared to 27% and 1% in normal healthy subjects.Diclofenac is eliminated through metabolism and subsequent urinary and biliary excretion of the glucuronide and the sulfate conjugates of the metabolites. Voltaren® (diclofenac sodium enteric-coated tablets) is a benzene-acetic acid derivative. Used to relieve mild-to-moderate acute pain associated with osteoarthritis and rheumatoid arthritis. Elevations in transaminases were seen more frequently in patients with osteoarthritis than in those with rheumatoid arthritis. Anaphylactoid reactions have been reported with therapeutic ingestion of NSAIDs, and may occur following an overdose. Available for Android and iOS devices. Both diclofenac and its oxidative metabolites undergo glucuronidation or sulfation followed by biliary excretion.