However, after 2 years I feel that it doesn't work that well anymore, so I have decided to switch to Lexapro (escitalopram). And trying new meds can make people suicidal? Some antidepressants must not be combined.Antidepressants can cause withdrawal syndromes if discontinued abruptly after prolonged use. For a better experience, please enable JavaScript in your browser before proceeding. NPS MedicineWise disclaims all liability (including for negligence) for any loss, damage or injury resulting from reliance on or use of this information. I have been feeling a bit sick in the tummy which brings on anxiety but I think most of the anxiety has been my brain making it worse from expecting this changeover to be rough, I hear some people come off Mirtz really bad? Serotonin modulators: Limited data, direct switch within class at approximate equivalent dose or cross-taper outside of class Mirtazapine to other antidepressant: Cross taper Approximate dose conversions for select antidepressants*: Drug Approximate Equivalent Dose (mg) SSRIs Citalopram 20 Escitalopram 10 Fluoxetine 20 Paroxetine 20 After assuring correct diagnosis, optimal dose, duration and adherence to treatment, a change of antidepressant drug is indicated. Some patients experience little discomfort despite abrupt cessation, while others are severely affected. Prevention through minimising interactions between potent serotonergic drugs is critical. Switching from one antidepressant to another requires careful observation and caution. 24 Jun 2020 I was on Mirtazapine (30mgs) but because of it making me put on 11kgs and making me too sleepy and my circulation go weird I lowered to (15mgs) a night on Sunday and started taking Lexapro (10mgs) every morning, I have to use both of these until I see my doctor next Friday. Hi all, I generally have social anxiety but the past six months have had nasty panic disorder. Hay I took mirazapine for awhile and it makes ya gain weight and I'm not sure what the effects are coming off it I'm pretty sure bad considering what happend wen I went off them but the sister of cipralex is pretty helpful especially with anxiety it seems pretty harmless to me but I'm no doctor Hi, I'm taking 15mg Mirtazapine in the evening. But as I feel so awful anyway once I get over this the benefits of taking the meds make it worthwhile.