Your doctor may suggest you reduce the dose gradually before stopping treatment. Pack sizes of 10, 30, 50, 60 and 100 tablets are registered for all strengths. If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby ask your doctor for advice before taking this medicine. Your doctor will decide on your starting dose. Seroquel XL 300 mg prolonged-release tablets and Seroquel XL 400 mg prolonged-release tablets contain 27 mg sodium (main component of cooking/table salt) in each tablet. You might ask them to tell you if they think your depression is getting worse, or if they are worried about changes in your behaviour. [6] [7] Despite being widely used as a sleep aid due its sedating effect, the benefits of such use do not appear to generally outweigh the side effects. Seroquel XL does not require any special storage conditions. 8 0.28000000000000003 36. If you take more Seroquel XL than prescribed by your doctor, you may feel sleepy, feel dizzy and experience abnormal heart beats. 9 5 30 12.17 36. It was 13-16% more effective than There is tentative evidence of the benefit of quetiapine versus placebo in schizophrenia; however, definitive conclusions are not possible due to the high rate of attrition in trials (greater than 50%) and the lack of data on economic outcomes, social functioning, or quality of life.A Cochrane review comparing quetiapine to other atypical antipsychotic agents tentatively concluded that it may be less efficacious than Quetiapine does not decrease agitation among people with Both typical and atypical antipsychotics can cause Weight gain can be a problem for some, with quetiapine causing more weight gain than As with some other anti-psychotics, quetiapine may lower the There is tentative evidence that discontinuation of antipsychotics can result in psychosis.Placental exposure is least for quetiapine compared to other atypical antipsychotics.Most instances of acute overdosage result in only sedation, hypotension and tachycardia, but cardiac arrhythmia, coma and death have occurred in adults. These measures will help to protect the environment. In an 8-week bipolar depression disorder study, SEROQUEL XR started to improve overall symptom scores of depression as early as week 1 and continued to improve throughout the study (vs placebo). 50 mg tablets are peach coloured; 150 mg tablets are white coloured; 200 mg tablets are yellow coloured; 300 mg tablets are pale yellow coloured and 400 mg tablets are white coloured. 6 100 0.53 36. Additional side effects in children and adolescents The same side effects that may occur in adults may also occur in children and adolescents. If you suddenly stop taking Seroquel XL, you may be unable to sleep (insomnia), or you may feel sick (nausea), or you may experience headache, diarrhoea, being sick (vomiting), dizziness or irritability. 2 100 0.96 36. You can also report side effects directly via the Yellow Card Scheme Website: Keep this medicine out of the sight and reach of children. Weight gain has been seen in patients taking Seroquel XL. SEROQUEL, you may have side effects such as trouble sleeping or trouble staying asleep (insomnia), nausea, and vomiting. Your tablets may make you feel sleepy. 2. This belongs to a group of medicines called anti-psychotics. You may find it helpful to tell a relative or close friend that you are depressed, and ask them to read this leaflet. If you are depressed you may sometimes have thoughts of harming or killing yourself. What Seroquel XL looks like and contents of the pack All prolonged-release tablets are capsule shaped and marked with XR and the strength. These may be increased when first starting treatment, since these medicines all take time to work, usually about two weeks but sometimes longer. 7 100 0.57999999999999996 36. If you have any further questions on the use of this medicine, ask your doctor or pharmacist. Serum or plasma quetiapine concentrations are usually in the 1–10 mg/L range in overdose survivors, while postmortem blood levels of 10–25 mg/L are generally observed in fatal cases.Quetiapine has the following pharmacological actions:At very low doses, quetiapine acts primarily as a histamine receptor blocker (antihistamine) and When treating schizophrenia, antagonism of D2 receptor by quetiapine in the mesolimbic pathway relieves positive symptoms and antagonism of the 5HT2A receptor in the frontal cortex of the brain relieves negative symptoms.The synthesis of quetiapine begins with a dibenzothiazepinone.