doi: 10.1080/02724936.1984.11748334. DESCRIPTION. Snyder MJ, Gonzalez O, Palomino C, Music SI, Hornick RB, Perroni J, Woodward WE, Gonzalez C, DuPont HL, Woodward TE.Lancet. 1987 Jul-Aug;9(4):719-36. doi: 10.1093/clinids/9.4.719.Cochrane Database Syst Rev. Name must be less than 100 characters 532 CHLOR~AMPHENICOL IN TYPHOID FEVER (3) The failure of chloramphenicol to reduce the carrier rate, the relapse rate and the incidence of complications is disappointing. 2008 Oct 8;(4):CD006083. The following information includes only the average doses of this medicine. Unable to load your delegates due to an error of body-weight over the first two hours, and then 25 mg. per kg. days compared with 7 (2.6) days with the lower dose (P less than 0.01). Chloramphenicol is best taken with a full glass (8 ounces) of water on an empty stomach (either 1 hour before or 2 hours after meals), unless otherwise directed by your doctor. In the past, the drug of choice was chloramphenicol. Use only as alternative for treatment of meningitis, typhoid, or rickettsial infection – Severe typhoid fever if the strain is susceptible (recent drug susceptibility test) Forms and strengths, route of administration – 1 g powder for injection, to be dissolved in 10 ml of water for injection, for IV injection over 1 to 2 minutes. SUMMARY OF RESULTS (1) Response to chloramphenicol in a series of 110 cases of typhoid fever is presented. 50 mg/kg/day IV divided q6hr; in exceptional cases, patients with moderately resistant organisms or severe infections may require increased dosage up to 100 mg/kg/day; decrease these high doses as soon as possible . Chloramphenicol is an antibiotic that is clinically useful for, and should be reserved for, serious infections caused by organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. 1976 Nov 27;2(7996):1155-7. doi: 10.1016/s0140-6736(76)91678-0.Am J Dis Child. All examinations were standardised and entered into case record forms. Follow your doctor's orders or the directions on the label. Name must be less than 100 characters The physicians re-examined the patients on days 8 and 15, and at 1, 3, and 6 months. 6 years and older: 1 capsule orally, on days 1, 3, 5, and 7, 1 hour before a meal, with cold or lukewarm fluids Comments:-The course should be completed at least 1 week before potential exposure to S. typhi.-Efficacy has been shown to persist for at least 5 years -Routine immunization is not recommended.-Immunization is recommended for travelers … Other Indications & Uses. 1987 Aug;141(8):862-5. doi: 10.1001/archpedi.1987.04460080048025.Rev Infect Dis. Age. Its use by mouth or by injection is only recommended when safer antibiotics cannot be used. We comply with the HONcode standard for trustworthy health information - In the 6 treated cases, a total dosage of 19-22 g. of the drug; given in eight days, did not prevent relapses or the development of the carrier state. Dosage of chloramphenicol in typhoid and paratyphoid in children. We comply with the HONcode standard for trustworthy health information - Rest in bed and symptomatic treatment should continue, as before chloramphenicol therapy, for at least another week. Clipboard, Search History, and several other advanced features are temporarily unavailable. In the children who received only chloramphenicol, the higher dose produced a clinical response in 5.4 (1.8) (mean (S.D.] Treatment failed in 63% with the lower dose and in 24% of children treated with the higher dose (P less than 0.001). Children, especially new- borns and young infants, metabolize chloramphenicol much more slowly than do adults. 2008 Oct 8;(4):CD006083. Monitoring both blood levels of the medication If your dose is different, do not change it unless your doctor tells you to do so.