Although normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with the "gasping syndrome", the minimum amount of benzyl alcohol at which toxicity may occur is not known.The risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneys' capacity to detoxify the chemical. It can also be used to treat acne, and some cases of methicillin-resistant Staphylococcus aureus. Benzyl alcohol can cross the placenta (see Limited published data based on breast milk sampling reports that clindamycin appears in human breast milk in the range of less than 0.5 to 3.8 mcg/mL at dosages of 150 mg orally to 600 mg intravenously. Each mL contains the equivalent of 150 mg clindamycin, 0.5 mg disodium edetate and 9.45 mg benzyl alcohol added as preservative in each mL. Therefore, it should be used with caution in patients receiving such agents.Clindamycin is metabolized predominantly by CYP3A4, and to a lesser extent by CYP3A5, to the major metabolite clindamycin sulfoxide and minor metabolite N-desmethylclindamycin. Your symptoms may improve before the infection is completely cleared. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C difficile.C. Clindamycin undergoes metabolism, presumably in the liver, to the active N-demethyl and sulphoxide metabolites, and also some inactive metabolites and about 4% in the faeces: the remainder is excreted as inactive metabolites. Clindamycin may also be used for purposes not listed in this medication guide. Lincosamides such as clindamycin bind to the 50S subunit of the bacterial ribosome similarly to macrolides such as erythromycin and inhibit the early stages of protein synthesis. They do not treat viral infections (e.g., the common cold). Clindamycin cannot readily be removed from the blood by haemodialysis or peritoneal dialysis.If an allergic adverse reaction occurs, therapy should be with the usual emergency treatments, including corticosteroids, adrenaline and antihistamines.Clindamycin is a lincosamide antibiotic with a primarily bacteriostatic action against Gram-positive aerobes and a wide range of anaerobic bacteria. It is also used before dental procedures or surgery to prevent infections in people who have heart conditions that put them at greater risk of infection. It is an antibiotic that works by stopping the growth of bacteria. This reaction may occur several weeks after you began using clindamycin.Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. Do not double the dose to catch up.Store at room temperature away from light and moisture. Clindamycin may also be used for purposes not listed in this medication guide.Clindamycin can cause diarrhea, which may be severe or lead to serious, life-threatening intestinal problems. In patients with moderate to severe liver disease, prolongation of clindamycin half-life has been found. The higher doses would be used for more severe infections. Properly discard this product when it is expired or no longer needed. Close monitoring is also recommended in patients with renal or hepatic insufficiency and in neonates and infants, all of whom may require dose reduction and/or an extended interval between doses.Prolonged administration of Clindamycin capsules, as with any anti-infective, may result in super – infection due to organisms resistant to clindamycin.Care should be observed in the use of Clindamycin capsules in atopic individuals.Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.The choice of clindamycin should be based on factors such as severity of the infection, the prevalence of resistance to other suitable agents and the risk of selecting clindamycin-resistant bacteriaClindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents. Because of the potential for serious adverse reactions in nursing infants clindamycin should not be taken by nursing mothers.In animal studies, clindamycin had no effect on fertility or mating ability (see Section 5.3).Clindamycin has no or negligible influence on the ability to drive and use machines.The table below lists the adverse reactions identified through clinical trial experience and post-marketing surveillance by system organ class and frequency. Available for Android and iOS devices. Protect the Do not store the oral liquid in the refrigerator. It should be used with caution, therefore, in patients receiving such agents.Antagonism has been demonstrated between clindamycin and erythromycin Increased coagulation tests (PT/INR) and/or bleeding, have been reported in patients treated with clindamycin in combination with a vitamin K antagonist (e.g. Because animal reproduction studies are not always predictive of the human response, this drug should be used during pregnancy only if clearly needed.Reproduction studies performed in rats and mice using oral doses of clindamycin up to 600 mg/kg/day (2.1 and 1.1 times the highest recommended adult human dose based on mg/mClindamycin Injection contains benzyl alcohol. Important information.