advice about side effects. The Ortho Tri-Cyclen Lo brand name has been discontinued in the U.S. help if any of these side effects or any other side effects bother you or do not go away: Do not use Ortho Tri-Cyclen Lo for a condition for which it was not prescribed. The dose of replacement thyroid hormone or cortisol therapy may need to be increased.A woman who is taking COCs should have a yearly visit with her healthcare provider for a blood pressure check and for other indicated healthcare.In women with hereditary angioedema, exogenous estrogens may induce or exacerbate symptoms of angioedema.Chloasma may occasionally occur, especially in women with a history of chloasma gravidarum. If bleeding persists or occurs after previously regular cycles, check for causes such as pregnancy or malignancy. The racial demographic of those treated with Ortho Tri-Cyclen Lo was: Caucasian (86%), African-American (6%), Asian (2%), and Other (6%). Ortho Tri-Cyclen and Ortho Tri-Cyclen Lo are both medications which prevent ovulation (and pregnancy) using female hormones. For this reason, COCs are contraindicated in women who are over 35 years of age and smoke Complete instructions to facilitate patient counseling on proper tablet usage are located in the FDA-Approved Patient Labeling.Starting COCs in women not currently using hormonal contraception (Day 1 Start or Sunday Start)Due to the potential risk of becoming pregnant, use additional non-hormonal contraception (such as condoms and spermicide) for the first seven days of the patient's first cycle pack of Ortho Tri-Cyclen Lo.Switching to Ortho Tri-Cyclen Lo from another oral contraceptiveSwitching from another contraceptive method to Ortho Tri-Cyclen LoStarting Ortho Tri-Cyclen Lo after Abortion or MiscarriageAdditional non-hormonal contraception (such as condoms and spermicide) should be used as back-up if the patient has sex within 7 days after missing tablets.Additional non-hormonal contraception (such as condoms and spermicide) should be used as back-up if the patient has sex within 7 days after missing tablets.Use of Hepatitis C drug combinations containing ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, due to the potential for ALT elevations During clinical trials with the Hepatitis C combination drug regimen that contains ombitasvir/paritaprevir/ritonavir, with or without dasabuvir, ALT elevations greater than 5 times the upper limit of normal (ULN), including some cases greater than 20 times the ULN, were significantly more frequent in women using ethinyl estradiol-containing medications, such as COCs. COCs can reduce milk production in breastfeeding mothers. Accumulation following multiple dosing of the 0.180 mg NGM / 0.025 mg EE dose is approximately 1.5 to 2 fold for NGMN and approximately 1.5 fold for EE compared with single dose administration, in agreement with that predicted based on linear kinetics of NGMN and EE. The pregnancy rate in women aged 18 to 35 years was approximately 2.6 pregnancies per 100 woman-years of use.Ortho Tri-Cyclen Lo Tablets are available in a single pouch containing a VERIDATE blister card (refill) of 28 tablets: NDC 50458-251-28. These drugs also change the cervical mucus and uterine lining in a womans cervix. The Ortho Tri-Cyclen Lo brand name has been discontinued in the U.S. If you think there has been an overdose, call your poison control center or get medical care right away. Call your doctor or get medical If Ortho Tri-Cyclen Lo (ethinyl estradiol and norgestimate) is stopped, your doctor will tell you when to start taking Ortho Tri-Cyclen Lo (ethinyl estradiol and norgestimate) again after your surgery or procedure. Some other examples of serious blood clots include blood clots in the legs or eyes.Call your healthcare provider or go to a hospital emergency room right away if you have:changes in the sugar and fat (cholesterol and triglycerides) levels in your bloodnew or worsening headaches including migraine headachesirregular or unusual vaginal bleeding and spotting between your menstrual periods, especially during the first 3 months of taking Ortho Tri-Cyclen Lo.swelling of your skin especially around your mouth, eyes, and in your throat (angioedema).dark patches of skin around your forehead, nose, cheeks and around your mouth, especially during pregnancy (chloasma).What are the most common side effects of Ortho Tri-Cyclen Lo?What else should I know about taking Ortho Tri-Cyclen Lo?General information about the safe and effective use of Ortho Tri-Cyclen Lo.What should I know about my period when taking Ortho Tri-Cyclen Lo?Important Information about taking Ortho Tri-Cyclen LoIf you start taking Ortho Tri-Cyclen Lo and you have not used a hormonal birth control method before:If you start taking Ortho Tri-Cyclen Lo and you are switching from another birth control pill:If you start taking Ortho Tri-Cyclen Lo and previously used a vaginal ring or transdermal patch:If you start taking Ortho Tri-Cyclen Lo and you are switching from a progestin-only method such as an implant or injection:If you start taking Ortho Tri-Cyclen Lo and you are switching from an intrauterine device or system (IUD or IUS):Ortho Tri-Cyclen Lo comes in either a DIALPAK pill dispenser or a VERIDATE pill dispenser.