); and Anthony Marlon, MD (Las Vegas, Nev.)We use cookies to help provide and enhance our service and tailor content and ads. isosorbide dinitrate. Although some questions remain regarding the diagnosis and mortality of CHF in the doxazosin arm and regarding the risk of dying from malignancy in the diuretic arm of ALLHAT, drugs used to treat hypertension should lower the CHF risk. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. Doxazosin is contraindicated in patients with a hypersensitivity to doxazosin, other quinazolines (e.g., prazosin, terazosin), or any of its components. Adrenergic alpha-Antagonists: Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. Messerli F.H. prazosin, doxazosin treat HTN and BPH. OpenUrl CrossRef PubMed. 1967-1975. JAMA 2000; 283: 1967-1975. Therefore, until ironclad safety data are provided, doxazosin, and probably all alpha-blockers, should no longer be used as first-line antihypertensive therapy.We use cookies to help provide and enhance our service and tailor content and ads. Medical Information Search. Doxazosin must be used with caution, especially with initial dosing, as hypotension may occur. Renin-angiotensin axis blockers such as enalapril and valsartan, which vv AngII production selectively cause dilation of arteries/veins. Doxazosin was associated with a significantly higher level of voluntary submaximal exercise and a favorable trend on left ventricular ejection fraction (increase of 9.8% of the baseline value vs 2.7% with placebo; Supported by a research grant from Pfizer Central Research, Groton, Conn.The principal investigators, coworkers, and respective medical centers for this study are listed: Robert DiBianco, MD, Paula Goldberg PA-C, Keith M. Lindgren, MD, James A. Ronan Jr., MD, Dennis J. Donohue, MD, Louis J. Larca, MD (Washington Adventist Hospital, Takoma Park, Md), and Steven N. Singh, MD, John S. Gottdiener, MD, Andrew I. Cohen, MD, Joshua Cutler, MD, Benjamin Lee, MD, Ross D. Fletcher, MD, (Veterans Administration Medical Center, Washington, D.C.); John O. Parker, MD, (Queen's University, Kingston, Ontario, Canada); Simon Chakko, MD, Karen Olichwier, RN, (Veterans Administration Medical Center, Salem Va); Paul H. Tanser, MD, (St. Joseph's Hospital, Hamilton, Ontario); George Emmanuel, MD, Thiam H. Lie, MD, Jill M. Ireland, RRT, CPFT (Pulmonary Disease Section, Bay Pines Veterans Administration Medical Center, Bay Pines, Fla., and the University of South Florida, College of Medicine, Tampa, Fla.); Jang B. Singh, MD, Stephen Pezzella, MD (Saint Vincent Hospital, Inc. Worcester, Mass. JAMA 2000; 283: 1967-1975. Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. Treatment groups were evaluated with respect to symptoms of heart failure, indexes of quality of life and left ventricular function, frequency and type of arrhythmia, adverse events, and mortality rates. Tolerance can develop. Recent data from the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) have shown the risk of CHF to be twice as high with doxazosin than with chlorthalidone. vasodilation > venodilation. i O Doxazosin: onstrated antihypertensive efficacy 8-10 and favorable effects on serum lipid fractions that include reducing the level of low-density lipoprotein cholesterol, suggested to occur through increases in the number or activity of the low-density lipoprotein receptors. another alpha-blocker—prazosin, 5 mg twice a day—also showed no benefits in patients with CHF when compared with placebo, whereas cumulative mortality was lowered by 38% with combination therapy of isosorbide dinitrate and hydralazine (5). Alfuzosin oral tablet is a prescription medication used to treat benign prostatic hyperplasia (BPH), which is also called enlarged prostate. Website summaries. After a stabilization period of at least 2 weeks with digitalis and diuretics, 73 patients with chronic CHF were randomized to receive additionally either doxazosin or placebo in double-blind fashion. Doxazosin (11.9 ± 0.9 mg) given once daily produced a favorable trend in the investigators' and patients' assessments of symptomatic change. Doxazosin: A prazosin-related compound that is a selective alpha-1-adrenergic blocker. In the Vascular Heart Failure Trial study, treatment with another alpha-blocker—prazosin, 5 ... (14% vs. 9%) higher in patients ... ALLHAT Collaborative Research GroupMajor cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) JAMA, 283 (2000), pp. Serum profile of isosorbide mononitrate after vaginal administration in the third trimester - Strathprints