ISENTRESS chewable tablets may be chewed or swallowed whole. Interim statement regarding potential fetal harm from exposure to dolutegravir – implications for HIV post-exposure prophylaxis (PEP). Coverage of PEP varies across and even within some provinces; check with your pharmacist or sexual health clinic for information on subsidized access to PEP in your region.Until recently, the anti-HIV drug dolutegravir (Tivicay) was commonly used as part of PEP regimens, usually along with the drugs TDF + FTC. For PEP to work, it must be initiated within 72 hours of exposure and taken every day for 28 consecutive days, exactly as directed. ISENTRESS film-coated tablets must be swallowed whole. Bei hohem Risiko ist folgende Postexpositionsprophylaxe (PEP) zu empfehlen: Truvada ® und Isentress ® (Raltegravir) werden in der Regel gut vertragen. ISENTRESS HD is a prescription HIV medicine used with other antiretroviral medicines to treat HIV-1 infection in adults, and in children weighing at least 88 pounds (40 kg). Isentress® is one of the newest classes of antiretrovirals, the intergrase inhibitors. The CDC says that healthcare providers prescribing PEP should avoid the use of dolutegravir for:“The preferred regimen for these women is raltegravir (Isentress) + tenofovir + FTC (emtricitabine). should raltegravir be unavailable).”“The CDC currently recommends that prior to starting PEP all women of childbearing potential should have a pregnancy test performed. As Isentress® is a relatively new drug it is likely there are other drugs it will react with in a negative way that are not yet known. There is no indication it is harmful to the baby, but not enough information to say that it isn’t. You should never breastfeed while on PEP, not only because the medication is transmitted through breastmilk but also to prevent transmission of HIV virus that has not been inactivated. While not approved for treatment of HBV there are clinical trials currently assessing its effectiveness against HBV and it may offer hope in future for HBV sufferers.Epstine-Barr virus (EBV) is a member of the Herpesviridae family (It is a wonderful example of cross-discipline drug development where eagle-eyed doctors noticed a correlation between use of a drug for one purpose and followed through with their observations. The result of which is a HIV drug that not only provides hope for those with HIV, but spreads out to potentially treat cancer and autoimmune disease as well.Watch this space, very exciting developments going on.Information on use of Isentress® in treatment of relapsing Multiple Sclerosis This way, it gives room for the immune system to become stronger and more active against opportunistic infections. Keine Dosisanpassung bei Patienten mit eingeschränkter Nierenfunktion sowie leicht bis mäßig eingeschränkter Leberfunktion. Do not take any more of the medication if these symptoms appear until given the all clear by your doctor.As with all PEP drugs, hepatitis or other liver conditions and any kidney conditions need to be closely monitored while taking Isentress®. However, individual circumstances may dictate consideration of alternatives (eg. If you feel unwell after taking another medication in combination with Isentress® inform your doctor immediately. Seek emergency medical assistance should you find a rash in combination with fever, extreme tiredness, unexplained muscle or joint pains, sores in the mouth, swelling around the eyes or inside the mouth or difficulty breathing. It belongs to an integrase strand transfer inhibitor (also called INSTI) class of drugs. This drug disables the HIV intergrase protein which is responsible for integrating the viral genome into the human chromosome and causing the chronic incurable … ISENTRESS for oral suspension: Using the provided mixing cup, combine 10 mL of water and the entire contents of one packet of ISENTRESS for oral suspension and mix. One to watch for is Magnesium supplements. Like Viread, Isentress® can cause a rebound effect in HBV sufferers as it is believed to lower HBV loads which recover when PEP treatment is stopped causing a bout of acute hepatitis. As both of these alternatives directly impact on viral replication, it would suggest that the intergrase has a more essential role in HIV replication that previously thought.Work on other viruses, notably Hepatitis B (HBV) and Epstin-Barr virus have shown that despite being designed for HIV, Isentress® may be effective against a much wider range of viruses.