If you have kidney problems. However, some case reports have been recently published on severe viral infections following administration of rituximab. Epub 2011 Jun 15.Tsutsumi Y, Yamamoto Y, Shimono J, Ohhigashi H, Teshima T.World J Hepatol. informational and educational purposes only. 2005 May;4(3):599-608. doi: 10.1517/14740338.4.3.599.Expert Opin Biol Ther. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvZXBpdmlyLWhidi1sYW1pdnVkaW5lLTM0MjYyMQ== If you have been tested and know whether you have a particular gene variation called HLA-B*5701. CrCl ≥ 50 mL/min: 150 mg PO q12hr or 300 mg PO qDay. A 53-year-old man who had a history of fluminant hepatitis caused by precore mutant hepatitis B virus (HBV) was admitted to our hospital for the treatment of relapsed non-Hodgkin's lymphoma in July 2000. We initiated lamivudine at a daily dose of 75 mg to prevent HBV proliferation during chemotherapy. Epub 2012 Nov 21. There currently is no generic version of this drug in the United States. Rituximab should be used cautiously for patients with HBV infection, but prophylactic administration of lamivudine may be beneficial for preventing reactivation of HBV. Discussion. 2016 Jun 28;4(2):143-50. doi: 10.14218/JCTH.2016.00005. Please enable it to take advantage of the complete set of features! At present, four months after the completion of chemotherapy, he continues lamivudine, and the titer of HBs antigen is low at 4-fold. Epub 2004 Aug 25.Tsutsumi Y, Kanamori H, Mori A, Tanaka J, Asaka M, Imamura M, Masauzi N.Expert Opin Drug Saf. By September 2000, he had received six courses of rituximab at 375 mg/m(2) and four courses of fludarabine and mitoxantrone. 2004 Dec;83(12):769-74. doi: 10.1007/s00277-004-0899-y. In fact, Lamivudine was originally developed as a drug treatment for HIV and was then found to be an effective antiviral for the treatment of hepatitis B. CrCl . CrCl ≥ 50 mL/min: 150 mg PO q12hr or 300 mg PO qDayCrCl 15-29 mL/min: 150 mg first dose, then 100 mg qDayCrCl 5-14 mL/min: 150 mg first dose, then 50 mg qDayIndicated for treatment of HIV infection in combination with other antiretroviral agents≥2 years: 3 mg/kg PO qDay; not to exceed 100 mg/day Lamiduvine 150-mg scored tablet is the preferred formulation for HIV-1 infected children and adolescents ≥14kg and whom a solid dosage form is appropriateTablet regimens are recommended when possible to avoid potential interactions with sorbitolConsider more frequent monitoring of HIV-1 viral load when treating with lamiduvine (Epivir) oral solution; see also warnings and precautions sectionAnemia (including pure red cell aplasia and severe anemias progressing on therapy), lymphadenopathy, splenomegaly, thrombocytopeniaLactic acidosis and severe hepatomegaly with steatosis (including fatal cases) reported with use of nucleoside analogues alone or in combination with other antiretrovirals; discontinue therapy if clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity occurEpivir-HBV is not FDA approved for treatment of HIV-1 infection; lamivudine dosage in EPIVIR-HBV is subtherapeutic and monotherapy is inappropriate for the treatment of HIV-1 infection and the safety and efficacy of this drug have not been established in patients co-infected with HBV and HIV; severe acute exacerbations of hepatitis B reported in patients who have discontinued anti-hepatitis B therapy (including HBV formulation); hepatic function should be monitored closely with both clinical and laboratory follow-up for at least several months in patients who discontinue anti-hepatitis B therapy; if appropriate, initiation of anti-hepatitis B therapy may be warrantedTablets and oral solution formulations used to treat HIV infection contain a higher dose of lamivudine than formulations indicated for chronic hepatitis B infection; HBV is not approved for treatment of HIV-1 infection because lamivudine dosage in HBV formulation is subtherapeutic and monotherapy is inappropriate for treatment of HIV-1 infection; patients with HIV should receive only formulation specific for HIVLactic acidosis and severe hepatomegaly with steatosis, including fatal cases, reported with use of nucleoside analogues, including lamivudine; a majority of these cases have been in women; female sex and obesity may be risk factors for development of lactic acidosis and severe hepatomegaly with steatosis in patients treated with antiretroviral nucleoside analogues; suspend treatment in any patient who develops clinical or laboratory findings suggestive of lactic acidosis or pronounced hepatotoxicity, which may include hepatomegaly and steatosis even in the absence of marked transaminase elevationsExacerbation of hepatitis B in HBV/HIV coinfected patients may occur on discontinuationRisk of immune reconstitution syndrome if used in combination with other antiretroviral drugsDiscontinue immediately if signs or symptoms of pancreatitis occur in patients with history of pancreatitisEPIVIR-HBV is not appropriate for patients co-infected with HBV and HIV-1; if patient with unrecognized or untreated HIV-1 infection is prescribed EPIVIR-HBV for treatment of HBV, rapid emergence of HIV-1 resistance is likely to result because of subtherapeutic dose and inappropriate use of monotherapy for HIV-1 treatmentIn order to reduce risk of resistance in patients receiving monotherapy, consider a switch to alternative regimen if serum HBV DNA remains detectable after 24 weeks of treatment; optimal therapy should be guided by resistance testingPatients with HIV-1 infection should receive only dosage forms of lamivudine appropriate for treatment of HIV-1Emergence of lamivudine-resistant HBV variants associated with lamivudine-containing antiretroviral regimens reportedConcomitant administration of emtricitabine with lamivudine-containing products not recommendedHepatic decompensation (some fatal) reported in HIV-1/HCV co-infected patients receiving interferon and ribavirin-based regimens; monitor for treatment-associated toxicities; discontinue therapy as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or bothUse with caution in pediatric patients with a history of pancreatitis or other significant risk factors for pancreatitis; discontinue treatment as clinically appropriateA pregnancy registry has been established to monitor maternal-fetal outcomes of women exposed to lamivudine: 1-800-258-4263Available data from the APR show no difference in the overall risk of birth defects for lamivudine or zidovudine compared with background rate for birth defects of 2.7% in the Metropolitan Atlanta Congenital Defects Program (MACDP) reference population; APR uses the MACDP as the U.S. reference population for birth defects in the general population; MACDP evaluates women and infants from a limited geographic area and does not include outcomes for births that occurred at less than 20 weeks gestation; rate of miscarriage is not reported in the APRThe Centers for Disease Control and Prevention recommend that HIV-1-infected mothers in the United States not breastfeed infants to avoid risking postnatal transmission of HIV-1 infection; lamivudine is present in human milk; there is no information on effects of lamivudine or zidovudine on breastfed infant or effects of drugs on milk production; because of potential for (1) HIV-1 transmission (in HIV-negative infants), (2)developing viral resistance (in HIV-positive infants), and (3) serious adverse reactions in a breastfed infant, instruct mothers not to breastfeed if they are receiving therapyA: Generally acceptable. 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