It is taken by mouth. Name must be less than 100 characters Losartan is a non-peptide angiotensin II antagonist with antihypertensive activity. Kindling led to cardiac ischemic changes, which could be prevented by losartan and sodium valproate. 2011 Nov 9;(11):CD004022. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Clipboard, Search History, and several other advanced features are temporarily unavailable. This blocks the vasoconstricting and aldosterone-secreting actions of angiotensin II, leading to a decrease in blood pressure. HighWire Up to six weeks may be required for the full effects to occur. 2020 Feb;34(2):143-150. doi: 10.1038/s41371-019-0238-3. M. Barthelmebs etal Losartan andrenal lithium excretion activity was determined in animals treated by losartan or its solvent. This product is available in the following dosage forms:Portions of this document last updated: Sept. 01, 2020Copyright © 2020 IBM Watson Health. Effect of sodium chloride, enalapril, and losartan on the development of polycystic kidney disease in Han:SPRD rats Am J Kidney Dis . Our general interest e-newsletter keeps you up to date on a wide variety of health topics.Losartan is used alone or together with other medicines to treat high blood pressure (hypertension). Losartan is also used to decrease the risk of stroke in patients with high blood pressure and enlargement of the heart. A lower blood pressure will increase the supply of the blood and oxygen to the heart. It works by blocking a substance in the body that causes blood vessels to tighten. This site needs JavaScript to work properly. We use cookies to give you the best possible experience on our website. All rights reserved. 2002 Jun;25(6):1072-7. doi: 10.2337/diacare.25.6.1072.Mühlhauser I, Prange K, Sawicki PT, Bender R, Dworschak A, Schaden W, Berger M.Diabetologia. 2005 Aug;28(8):1862-8. doi: 10.2337/diacare.28.8.1862.Cochrane Database Syst Rev. Houlihan CA(1), Allen TJ, Baxter AL, Panangiotopoulos S, Casley DJ, Cooper ME, Jerums G. Author information: (1)Endocrine Unit and Department of Medicine, University of Melbourne, Austin, Australia. It is also used to treat kidney problems in patients with type 2 diabetes and a history of hypertension. Epub 2015 Mar 4.Chen AX, Moran JL, Libianto R, Baqar S, O'Callaghan C, MacIsaac RJ, Jerums G, Ekinci EI.J Hum Hypertens. Losartan is an angiotensin II receptor blocker (ARB). Unable to load your collection due to an error If you become pregnant while 2016 Dec 23;7:164. doi: 10.3389/fendo.2016.00164. If it continues for a long time, the heart and arteries may not function properly. The urinary lithium, creatinine, sodium, potassium, phosphate anduric acid concentrations were also determined. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement. Please enable it to take advantage of the complete set of features! eCollection 2018.Front Endocrinol (Lausanne). Sodium valproate per se caused cognitive impairment, which was prevented on combining with losartan or enalapril. Does losartan potassium lead to lower sodium levels? HighWire COVID-19 is an emerging, rapidly evolving situation. Upon administration, losartan and its active metabolite selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. 2016 Jul 28;8:50. doi: 10.1186/s13098-016-0159-z. 2018 Aug 21;11:427-438. doi: 10.2147/DMSO.S171365. All rights reserved. If so, would stopping - Answered by a verified Pharmacist. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.Mayo Clinic does not endorse companies or products. Epub 2019 Sep 9.Mihara Y, Kado H, Yokota I, Shiotsu Y, Sonomura K, Kusaba T, Hatta T, Matoba S, Tamagaki K.Sci Rep. 2019 Jun 19;9(1):8787. doi: 10.1038/s41598-019-45341-6.Wharton S, Raiber L, Serodio KJ, Lee J, Christensen RA.Diabetes Metab Syndr Obes. 2016 Jul;31(7):1081-7. doi: 10.1093/ndt/gfv033. eCollection 2016. High blood pressure adds to the workload of the heart and arteries. doi: 10.1002/14651858.CD004022.pub3.Keyzer CA, de Jong MA, Fenna van Breda G, Vervloet MG, Laverman GD, Hemmelder M, Janssen WM, Lambers Heerspink HJ, Navis G, de Borst MH; Holland Nephrology Study (HONEST) Network.Nephrol Dial Transplant.