Introduction. Criner GJ, Celli BR Failure of low-dose theophylline to prevent exacerbations in patients with COPD. If theophylline dose adjustments are made, re-adjust the dose upon completion of boceprevir treatment. Effect of theophylline as adjunct to inhaled corticosteroids on exacerbations in patients with COPD. Devereux G, Cotton S, Fielding S, et al. Caution is recommended.The manufacturer product information should be consulted for formula specific adjustments based on serum concentrations.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Design, setting, and participants: The TWICS (theophylline with inhaled corticosteroids) trial was a pragmatic, double-blind, placebo-controlled, randomized clinical trial that enrolled patients with COPD between February 6, 2014, and August 31, 2016. Theophylline systemic 200 mg (WARRICK 1660) If theophylline is able to restore corticosteroid sensitivity in patients with COPD, as we have demonstrated in cells in vitro and animals in vivo, then the use of low-dose theophylline combined with a low dose of inhaled or even oral steroids may be effective as an antiinflammatory therapy and may even reduce the progression of the disease. A recent study sought to determine if adding low-dose theophylline to inhaled corticosteroids for COPD would reduce the number of exacerbations, and found that it did not. It works by relaxing the muscles in the lungs and chest, making it … Exacerbations drive morbidity, mortality, and the costs of care in patients with chronic obstructive pulmonary disease (COPD). Select one or more newsletters to continue. Oral theophylline has been used as a bronchodilator to treat Of the 1567 participants analyzed, the average age was 68.4 years and 54% (843) were men. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) currently recommends theophylline only in patients with chronic obstructive pulmonary disease (COPD) for whom other long-term bronchodilators are unavailable or unaffordable (NEJM JW Gen Med Jun 15 2017 and Am J Respir Crit Care Med 2017; 195:557).High-dose theophylline (i.e., plasma concentration, 10–20 mg/L) does … SAN DIEGO – For people with COPD at high risk of exacerbation, the addition of low-dose theophylline to inhaled corticosteroids conferred no overall clinical benefit, results from a … Theophylline is a bronchodilator that’s been used in the treatment of COPD for more than seven decades.It is used to treat wheezing or shortness of breath caused by asthma, bronchitis, emphysema and other breathing disorders. Objective: To investigate the effectiveness of adding low-dose theophylline to inhaled corticosteroids in COPD. Available for Android and iOS devices. Theophylline remains one of the most widely prescribed drugs for the treatment of asthma and chronic obstructive pulmonary disease (COPD) worldwide, since it is inexpensive and widely available. We comply with the HONcode standard for trustworthy health information - Applies to the following strengths: 100 mg; 200 mg; 400 mg/24 hours; 600 mg/24 hours; 125 mg; 300 mg; 450 mg; 80 mg/15 mL; 5%-40 mg/100 mL; 800 mcg/mL-D5%; 1.6 mg/mL-D5%; 2 mg/mL-D5%; 4 mg/mL-D5%; 3.2 mg/mL-D5%; 50 mg; 75 mg; 250 mg; 500 mg; 130 mg; 260 mg; 65 mg; 100 mg/24 hours; 200 mg/24 hours; 300 mg/24 hoursNo adjustment recommended in patients over 3 months of ageDose adjustment(s) may be required; however, no specific guidelines have been suggested. Peter J. Barnes, in Asthma and COPD (Second Edition), 2009. Although this interaction has not been studied, predictions about the interaction can be made based on the metabolic pathway of theophylline. Intravenous theophylline in dextrose: Loading dose, no theophylline in the previous 24 hours: 4.6 mg/kg ideal body weight, intravenously over 30 minutes, results in an average 10 mcg/mL (range 6 to 16) serum theophylline concentration-Calculate dose based on this formula: Concentration = loading dose / volume of distribution 2. Participants had a ratio of forced expiratory volume in the first second to forced vital capacity (FEVThe addition of theophylline did not significantly reduce the mean number of exacerbations compared with placebo over a 1-year period, the study found.In total, there were 3430 exacerbations: 1727 in the theophylline group (mean, 2.24 [95% CI, 2.10-2.38] exacerbations per year) versus 1703 in the placebo group (mean, 2.23 [95% CI, 2.09-2.37] exacerbations per year); unadjusted mean difference, 0.01 (95% CI, −0.19 to 0.21) and adjusted incidence rate ratio, 0.99 (95% CI, 0.91-1.08).Serious adverse events in the theophylline and placebo groups included cardiac (2.4% vs 3.4%, respectively), gastrointestinal (2.7% vs 1.3%), and adverse reactions such as nausea (10.9% vs 7.9%) and headaches (9.0% vs 7.9%).By 2020, COPD, which is largely preventable and often stems from smoking, is expected to be the third-leading cause of death.In an accompanying editorial, 2 physicians called the results “disappointing,” noting that the drug is inexpensive.1.