“There are theories formulated by researchers in which the anti-inflammatory effects of Metformin can be combined with healthy activities to synergistically impact aging,” states dermatologist Dr. Jeanine Downie.For example, one of the central mechanisms by which Metformin works is via its activation of the AMPK enzyme, which declines among older adults. It has not been approved by the FDA as an anti-aging treatment. PMID: 24756109 [Indexed for MEDLINE] Publication Types: Research suggests otherwise, however. report that metformin, an antidiabetic drug, inhibited melanogenesis, in vitro and in vivo, and they suggest that metformin may be used to treat hyperpigmentation disorders. I would only advise it if a patient’s primary care provider prescribed it to them for their elevated glucose or diabetic state.”There is still a great deal that researchers don’t know about Metformin. Published by Elsevier Inc. All rights reserved.ScienceDirect ® is a registered trademark of Elsevier B.V. By continuing you agree to the Copyright © 2020 Elsevier B.V. or its licensors or contributors. While there is evidence to suggest that Metformin may be an effective “Preserve the skin with anti-aging products containing ingredients like growth factors, antioxidants and neurotoxins to inhibit wrinkling. 2011 May. Downie does point out, however, that research into Metformin as an anti-aging drug is still in its infancy. A 41-year-old male presented to his physician with jaundice, fatigue, dark urine, and stool discoloration. Metformin-Induced Hepatitis Paliperidone-Related Peripheral Edema Vasospastic Angina Induced by Oral Capecitabine Skin Hyperpigmentation Due to Long-Term Voriconazole Therapy Vaccine-Associated Measles Michael A. Mancano, PharmD* The purpose of this feature is to heighten awareness of specifi c adverse drug reactions (ADRs), HA skincare products can supplement that loss, hydrating the skin, softening wrinkles, and Dermal fillers are comprised of synthetic or natural compounds that are injected into the skin. Metformin-Induced Hepatitis. ScienceDirect ® is a registered trademark of Elsevier B.V.Metformin: A Potential Drug to Treat Hyperpigmentation DisordersCopyright © 2014 The Society for Investigative Dermatology, Inc. Metformin has been clinically recognized to reduce aging processes within the body, and may also offer Metformin was developed as a type two diabetes drug and has been commonly prescribed in the U.S. for the treatment of the condition since 1995. South Med J. As we age, our hyaluronic acid reserves decrease. Replenish the skin with volumizers like dermal fillers and resurface the skin with chemical peels and laser ablation therapies.”Why Is Metformin Believed to Work As an Anti-aging Drug?Is There Any Evidence that Metformin Can Treat Aging Skin? “There have not been studies directly linking the medication and its anti-aging benefits,” she stresses.”The benefits at this time are largely theoretical and based on the understanding of the medication’s method of action. Background and methods: Irregular disfiguring skin hyperpigmentation due to inflammation may develop in black persons. Some studies have indicated Metformin may represent an effective anti-aging treatment for non-diabetic patients.The researchers found that Metformin delayed cellular aging and decreased reactive oxygen species (ROS) in dermal cells, which contribute to aging. Geddes ER, Cohen PR. Emerging research suggests it may help to slow or reverse visible signs of aging. Dermatologists have looked at metformin in a number of skin disorders, such as hormonal acne, hidradenitis suppurativa and acanthosis nigricans. The patient reported that his fatigue and yellow sclera had begun approximately 4 days prior to his seeking medical attention. 103(3):231-5. . When AMPK signaling is boosted, the body reaps a range of benefits, such as:These outcomes have significant consequences for healthspan and general wellbeing. 31(5):1753-5. While this might seem as unlikely as encountering the mythical fountain of youth, such a pill may, in fact, already exist. For example, many would assume that Metformin combined with exercise may further boost its anti-aging properties. Oxidative stress occurs when the body has trouble fighting off free radicals, which are caused by alcohol consumption, poor diet, stress levels and exposure to pollution. Antineoplastic agent-associated serpentine supravenous hyperpigmentation: superficial venous system hyperpigmentation following intravenous chemotherapy. Anticancer Res. It activates the AMPK enzyme, which allows cells to respond more effectively to insulin and absorb glucose from the blood.There is compelling research to indicate that Metformin may offer benefits for other therapeutic applications, in addition to diabetes. 2010 Mar. Finally, we confirmed the antimelanogenic effect of metformin on reconstituted human epidermis and on human skin biopsies. We investigated the treatment of this hyperpigmentation with topical tretinoin (0.1 percent retinoic acid cream). Serious reactions include lactic acidosis, megaloblastic anemia, and hepatotoxicity,” cautions Dr. Downie.Metformin is currently a prescription-only medication for diabetes patients.