Acne (Off-label) Females with hormonal acne. Our results demonstrate that low-dose spironolactone is effective in the treatment of hyperandrogenism in women. (PCOS). Two patients dropped out of the trial because of intolerance of the therapy. Lowering blood pressure can reduce the risk of strokes and heart attacks. I have PCOS but am also diabetic so the metformin works for both conditions and helps to control them both, when the dosage is right and my diet is good then the weight usually just falls off, but it is a lot more effective with daily exercise, gives the system a natural push in the right direction. Spironolactone tablets should always be administered with fluid and preferably with food to aid absorption. Spironolactone is used in combination with other medicines to treat high blood pressure (hypertension) and heart failure. Symptoms of PCOS such as excessive hair growth, acne, and absent periods respond well to OC-spironolactone treatment, with greater improvements with longer-term use. Spironolactone is also used to lessen the need for hospitalization for heart failure. Name must be less than 100 characters There was an excellent clinical response in 19 (61%), incomplete response in 8 (26%), no response in 5 women. Remarkable change of the menstrual pattern characterised as polymenorrhea was major side effect of the therapy. COVID-19 is an emerging, rapidly evolving situation. Range: 25-100 mg PO qDay. Spironolactone Dose I've been on Spiro for years, and it's always been the same 50mg twice a day dose. Something else may be happening with your other hormones, estrogen, progesterone, etc. --3 women, were treated with low dose spironolactone (50 mg or 75 mg daily) for average five months. Summary: Drug interactions are reported among people who take Ranitidine hydrochloride and Spironolactone together. 50-200 mg PO qDay or divided q12hr. ... 40 mg Omaprezole, 300 mg Ranitidine, .5 mg Enapril, Zyrtec, Women's Ultramega Multivitamin. Epub 2005 Aug 2. Will spironolactone cure my condition? For Adult. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. By mouth. It can help reduce excess facial and body hair and improve the thickness … --3 women, were treated with low dose spironolactone (50 mg or 75 mg daily) for average five months. Spironolactone caused statistically significant reduction in testosterone, luteinizing hormone and prolactin values at the end of the treatment. Unable to load your delegates due to an error Aldactone; Descriptions. Many women with PCOS have increased LH secretion and increased androgen activity in the skin due to increased 5-alpha reductase enzyme activity, which catalyzes the conversion of testosterone to the powerful intracellular androgen dihydrotestosterone. Spironolactone is a potassium-sparing diuretic (water pill). Congestive heart failure with oedema: For management of oedema an initial daily dose of 100 mg of spironolactone administered in either single or divided doses is recommended, but may range from 25 mg to 200 mg daily. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Unable to load your collection due to an error All rights reserved. This medicine is also used to treat or prevent hypokalemia (low potassium levels in the blood). Spironolactone is not a cure but taken long-term it can help control and sometimes clear acne. Drug information provided by: IBM Micromedex. Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). Dosing Modifications Renal impairment 9 Women with PCOS may present with a chief problem report of hirsutism, acne, or female androgenetic alopecia. Aldosterone is unrelated to your menstruation. Apparently it is a very common acne solution for people with pcos and it definately cleared up my skin right away. Lowering blood pressure can reduce the risk of strokes and heart attacks. An excellent clinical response in 19 ( 61 % ), incompl … Drug information provided by IBM... Gained 15-20 lbs dose I 've been on Spiro for years, and several other advanced features are unavailable! Mild diuretic that interferes with the action of a hormone called aldosterone spironolactone is used in combination with medicines... Prevent hypokalemia ( low potassium levels from getting too low the doctor told. 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