If you have an existing prescription from your doctor, you can purchase it from many pharmacies. Your chance of getting pregnant depends on how well you follow the directions for using Ortho Evra. Let’s start by exploring the side effects that have been linked with some of the most common birth control methods: Though the risk for side effects is certainly important to consider when choosing a birth control method, you might be more concerned about how effective it is.Based on these statistics, you can see how important it is to use your chosen method of birth control properly. You should apply a new patch each week for three weeks (21 total days). Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.Consult the labeling of concurrently-used drugs to obtain further information about interactions with hormonal contraceptives or the potential for enzyme alterations.Substances decreasing the plasma concentrations of CHCs and potentially diminishing the efficacy of CHCs:Drugs or herbal products that induce certain enzymes, including cytochrome P450 3A4 (CYP3A4), may decrease the plasma concentrations of CHCs and potentially diminish the effectiveness of CHCs or increase breakthrough bleeding. The results of these studies are presented in Figure 1.An increased risk of thromboembolic and thrombotic disease associated with the use of combination hormonal contraceptives (CHCs) is well established. However, the risk of liver cancers in CHC users is less than one case per million users.Ortho Evra is contraindicated in women with uncontrolled hypertension or hypertension with vascular disease An increase in blood pressure has been reported in women taking hormonal contraceptives, and this increase is more likely in older women with extended duration of use. Women using hormonal contraceptives should not smoke.Monitor blood glucose in women with diabetes. Discontinue Ortho Evra use if pregnancy is confirmed.Administration of CHCs should not be used as a test for pregnancy Carefully observe women with a history of depression and discontinue Ortho Evra if depression recurs to a serious degree.Ortho Evra is contraindicated in women who currently have or have had breast cancer because breast cancer may be hormonally sensitive There is substantial evidence that CHCs do not increase the incidence of breast cancer. However, steroid hormones may be poorly metabolized in patients with impaired liver function. Based on a model assumption that pregnancy duration is nine months, the rate is 7 to 27 per 10,000 WY.Some women have spotting or light bleeding, breast tenderness, or feel sick to their stomach during Ortho Evra use. If unscheduled bleeding persists longer than a few cycles, consider causes other than Ortho Evra.If the woman does not have scheduled or withdrawal bleeding (bleeding that should occur during the patch-free week), she should resume treatment on the next scheduled Change Day. This patch releases synthetic estrogen and progestin and allows a normal period after removal. Ortho-Cyclen Ortho Evra Patch Ortho-Novum 1/35; 777 Ortho-Novum 1/50 Ortho-Tri-Cyclen Ortho-Tri-Cyclen Lo Ovral Oxybutynin 5mg tab;1mg/ml soln Oxymetazoline 0.05% Nasal spray Pacerone 200mg tab Pamelor 25mg cap Pancrelipase cap Patanol ophth sol Paroxetine 20mg tab Paxil 20mg tab Pediaflor oral drops 1.1mg/ml Pediazole Susp The most common events leading to discontinuation were application site reaction, breast symptoms (including breast discomfort, engorgement and pain), nausea and/or vomiting, headache and emotional lability.Adverse drug reactions reported by ≥ 2.5% of Ortho Evra-treated subjects in these trials are shown in Table 3.Additional adverse drug reactions that occurred in < 2.5% of Ortho Evra-treated subjects in the above clinical trials datasets are:The following adverse reactions (Table 4) have been identified during post-approval use of Ortho Evra.