Applies to: Thrombocytopathy, Thrombocytopenia, Bleeding, Vitamin K Deficiency, Coagulation DefectNonsteroidal anti-inflammatory drugs (NSAIDs) reversibly inhibit platelet adhesion and aggregation and may prolong bleeding time in some patients. NSAIDs like diclofenac gel (1%) may affect egg release (ovulation) in women. 2016 Mar 2;15(2):87-9. doi: 10.5505/1304.7361.2015.33230. NSAIDs that selectively inhibit cyclooxygenase-2 (i.e., COX-2 inhibitors) do not appear to affect platelet function or bleeding time at indicated dosages and may be preferable if risk of bleeding is a concern.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. If renal function declines or renal failure occurs, prompt discontinuation of NSAID therapy will usually lead to recovery to the pretreatment state. Applies to: Peptic Ulcer, Gastrointestinal Hemorrhage, Duodenitis/Gastritis, Gastrointestinal Perforation, History - Peptic Ulcer, Alcoholism, Colitis/Enteritis (Noninfectious), Colonic Ulceration, SmokingNonsteroidal anti-inflammatory drugs (NSAIDs) can cause gastrointestinal mucosal damage, the risk of which appears to be related to both dosage and duration of therapy. Notable liver enzyme elevations exceeding 3 times the upper limit of normal have been reported in approximately 1% of patients in clinical trials. Applies to: Liver DiseaseBorderline elevations of serum transaminases, LDH, and alkaline phosphatase have been reported in up to 15% of patients treated with nonsteroidal anti-inflammatory drugs (NSAIDs). Patients should be advised to promptly seek medical attention if they experience symptoms that could indicate a cardiovascular thrombotic event such as chest pain, shortness of breath, weakness, and slurring of speech.Moderate Potential Hazard, Low plausibility. Atypon Applies to: PorphyriaThere has been an isolated report associating the use of diclofenac with precipitation of a porphyria attack. NSAIDs are also highly protein-bound and some are extensively metabolized by the liver. Rogers SY, Venning MC "Reversible acute renal failure precipitated by overdose of ibuprofen and salbutamol." Although not all NSAIDs have been studied, investigators believe it may be a class effect, and that the risk may be similar for all NSAIDs, both COX-2 selective and nonselective. Unable to load your collection due to an error Applies to: Dermatitis - Drug-InducedSevere, potentially fatal dermatologic reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, and other exfoliative dermatitis have been associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Available for Android and iOS devices. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.Major Potential Hazard, High plausibility. Anemia has been reported occasionally. We report one case of fatal salbutamol misuse or abuse in a 36-year-old poorly controlled female asthmatic patient with a past medical history of alcoholism and a recent smoking cessation. If diclofenac gel (1%) is swallowed, call a doctor or poison control center right away. Please enable it to take advantage of the complete set of features! Symptoms of an overdose In the case of an overdose, the above-mentioned undesirable effects (see 4.8, Undesirable effects) occur very quickly and with increased severity.