I do believe this med contributed to the insomnia, and maybe the frequent urination when i lay down? Doctor put me on muscle relaxers to help me get to sleep and stay asleep, but that didn't help; I still ended up waking up to go to the bathroom two or three times at night. I wasn't on that one, mine was another statin but I can tell you one thing, it kept me running to the bathroom all day and all night. This is still being studied. Lovastatin should be taken with dinner. ... might try that down the road in a low dose. for People in Need web site.WebMD does not provide medical advice, diagnosis or treatment. A "nocebo" effect means people who have negative expectations about a medication report experiencing the potential side effect at higher rates than the drug should cause.The actual risk of developing muscle pain as a result of taking statins is about 5 percent or less compared with taking a pill that doesn't contain medication (placebo). The frequent urination is still there but I will see a urologist as I think that is a separate problem. It appears you have not yet Signed Up with our community. Fla., Nov. 4-7, 2007. This causes your liver to remove cholesterol from your blood. Your doctor may be able to come up with an alternative treatment plan that can help you lower your cholesterol without uncomfortable side effects.Mayo Clinic does not endorse companies or products. There is limited evidence to prove a cause-effect relationship, but talk to your doctor if you experience memory loss or confusion while taking statins.There has also been evidence that statins may help with brain function — in people with dementia, for example. Inconvenient and disruptive to your daily life, frequent urination is when you need to urinate many times throughout a 24-hour period. Learn why you should take some statins at night. Also, i've heard some good thinkgs about the statin Pravachol (sp?) Depending on the particular medication and dosage, you may need to take your statin twice a day.Certain statins work better when taken with a meal. Frequent urination can cause a person to have too little potassium in his system and lead to negative health consequences. After taking it for 1-2 nights, I'm good for a while. I am going to check with my doctor and my new drug plan and see if something else will be covered and if my doctor will take me off of simvastatin. Happy Holidays..kimmie1 All rights reserved. This is because the cholesterol-making enzyme is more active at night. Risk factors include:Grapefruit juice contains a chemical that can interfere with the enzymes that break down (metabolize) the statins in your digestive system. Your diet should be packed with fruits, vegetables, whole grains, and fish. Many health professionals are convinced that statin-type cholesterol-lowering drugs do not cause any side effects. Study Shows Some Users of Zocor Report a Poorer Quality of SleepNov. Follow directions carefully for maximum effectiveness.Your doctor knows your personal medical issues and is your best source for information. I was only on 5mg. Rhabdomyolysis can occur when you take statins in combination with certain drugs or if you take a high dose of statins.Occasionally, statin use could cause an increase in the level of enzymes that signal liver inflammation. Medications or substances causing Frequent urination The following drugs, medications, substances or toxins are some of the possible causes of Frequent urination as a symptom. Data sources include IBM Watson Micromedex (updated 2 Sep 2020), Cerner Multum™ (updated 1 Sep 2020), … I found out that the frequent urination I was having was due to anxiety, not the simivastin. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research.© 1998-2020 Mayo Foundation for Medical Education and Research (MFMER).